1. It refers to the formula (I) derivative with R1 as h, hydroxy or alcoxi (C1-C6), which can be replaced by arilo (C6-C10)；R2 and R3 are substitutes for each h or hydrocarbon (C1-C6) and are replaced by hydroxyl or methoxy (C1-C6)；R4 es-c (o) nr5r6 o-nr7c (o) R8, wherein R5 is h or tar (C1-C6)；R6 is h, alcoxi (C1-C6),Arilo（C6-C10），R7 is, among other things, an alternative to h or tar (C1-C6)； R8 is tar (C1-C6),Alcoxi（C1-C6），Bicycle (C3-C6),There are others The most popular compound is formula (I),Page: 1There are others He also mentioned a pharmaceutical composer These compounds are quinase inhibitors of induction cells (ITK) that can be used in the treatment of rheumatoid arthritis.SE REFIERE A COMPUESTOS DERIVADOS DE INDOL DE FORMULA (I) DONDE R1 ES H, HIDROXI O ALCOXI(C1-C6) OPCIONALMENTE SUSTITUIDO CON ARILO(C6-C10)； R2 Y R3 SON CADA UNO H O ALQUILO(C1-C6) OPCIONALMENTE SUSTITUIDO CON HIDROXI O ALCOXI(C1-C6)； R4 ES -C(O)NR5R6 O -NR7C(O)R8, EN DONDE R5 ES H O ALQUILO(C1-C6)； R6 ES H, ALCOXI(C1-C6), ARILO(C6-C10), ENTRE OTROS； R7 ES H O ALQUILO(C1-C6) OPCIONALMENTE SUSTITUIDO； R8 ES ALQUILO(C1-C6), ALCOXI(C1-C6), CICLOALQUILO(C3-C6), ENTRE OTROS. SON COMPUESTOS PREFERIDOS LOS DE FORMULA (i), (ii), ENTRE OTROS. TAMBIEN SE REFIERE A UNA COMPOSICION FARMACEUTICA. DICHOS COMPUESTOS SON INHIBIDORES DE LA QUINASA DE LAS CELULAS T INDUCIBLE (ITK) SIENDO UTILES EN EL TRATAMIENTO DE ARTRITIS REUMATOIDE
