ASHWELL, Susan,CAMPBELL, Ann-Marie,CARAVELLA, Justin Andrew,DIEBOLD, R. Bruce,ERICSSON, Anna,GUSTAFSON, Gary,LANCIA, David R.,LIN, Jian,LU, Wei,WANG, Zhongguo
申请号：
PE2017000471
公开号：
PE20171056A1
申请日:
2015.09.18
申请国别(地区):
PE
年份:
2017
代理人:
摘要：
It refers to a pyridin-2 (1H) -on quinolinone derivative of formula I, where: W1 and W2 is CH, CF or N； W3 is CR2 or N； U is N or CR6； A is H, halogen, among others； R1 is OH, CN, among others； R2 is H, OH, among others； R3 is H, C1-C6 alkyl or -OH； R4 and R5 are H, halogen, among others； R6 is H, C1-C6 alkyl, among others； R9 is H, among others. Preferred compounds are: 5 - {[(6-chloro-2-oxo-1,2-dihydroquinolin-3-yl) methyl] amino} -1-methyl-6-oxo-1,6-dihydropyridin-2-carbonitrile； 6-chloro-3 - {[(1-ethyl-2-oxo-1,2-dihydropyridin-3-yl) amino] methyl} -1,2-dihydroquinolin-2-one；There are others He also mentioned a pharmaceutical composer These compounds are isotopic dehydrogenase mutant protein inhibitors (MT IDH), which have new morphological activities and can be used to treat cell proliferation and cancer disorders.Se refiere a un derivado de piridin-2(1H)-on quinolinona de formula I, donde: W1 y W2 es CH, CF o N； W3 es CR2 o N； U es N o CR6； A es H, halogeno, entre otros； R1 es OH, CN, entre otros； R2 es H, OH, entre otros； R3 es H, alquilo C1-C6 u -OH； R4 y R5 son H, halogeno, entre otros； R6 es H, alquilo C1-C6, entre otros； R9 es H, entre otros. Son compuestos preferidos: 5-{[(6-cloro-2-oxo-1,2-dihidroquinolin-3-il)metil]amino}-1-metil-6-oxo-1,6-dihidropiridin-2-carbonitrilo；6-cloro-3-{[(1-etil-2-oxo-1,2-dihidropiridin-3-il)amino]metil}-1,2-dihidroquinolin-2-ona； entre otros. Tambien se refiere a una composicion farmaceutica. Dichos compuestos son inhibidores de proteinas de isocitrato deshidrogenasa mutante (mt-IDH) con actividad neomorfica siendo utiles en el tratamiento de trastornos de proliferacion celular y cancer
