Disintegration is a most important step in absorption of poorly soluble drugs from tablet dosage form. Telmisartan is an Anti- hypertensive drug which is insoluble in water with bioavailability is only 42%. The objective of present invention is to synthesize starch tartrate as novel superdisintegrant by chemical modification of starch upon treating with tartaric acid. In the present invention starch tartrate, a novel polymer is synthesized, characterized and evaluated as disintegrant in tablets prepared by direct compression method. Fast disintegrating tablets of telmisartan 200mg were prepared by direct compression method incorporating starch tartrate as disintegrant at 5, 10, 15 % strength in the formula. The tablets were evaluated for the quality control parameters like weight variation, hardness, thickness, friability and drug content. The prepared tablets of starch tartrate have shown faster disintegration and dissolution profiles compared to those prepared using crosscarmellose sodium and sodium starch glycolate as superdisintegrants. The tablets were also evaluated in comparison to commercial brands.
