(Aralkylamino substituted in alpha and heteroarylalkylamino) pyrimidinyl and 1,3,5-triazinyl benzimidazoles, pharmaceutical compositions containing them, and these compounds for use in the treatment of proliferative diseases
A compound of formula II: ** Formula ** or an enantiomer, a mixture of enantiomers, a mixture of two or more diastereomers, or a variant isotopic thereof； or a pharmaceutically acceptable salt, solvate or hydrate thereof； wherein: X, Y, and Z are each independently N or CRx, with the proviso that at least two of X, Y, and Z are nitrogen atoms； where Rx is hydrogen or C1-6 alkyl； R1 and R2 are each independently (a) hydrogen, cyano, halo, or nitro； (b) C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C3-10 cycloalkyl, C6-14 aryl, C7-15 aralkyl, heteroaryl, or heterocyclyl； or (c) -C (O) R1a, - C (O) OR1a, - (O) NR1bR1c, -C (NR1a) NR1bR1c, -OR1a, - OC (O) R1a, -OC (O) OR1a, -OC (O) NR1bR1c, - OC (>； = NR1a) NR1bR1c, -OS (O) R1a, -OS (O) 2R1a, -OS (O) NR1bR1c, -OS (O) 2NR1bR1c, -NR1bR1c, -NR1aC (O) R1d, - NR1aC (O) OR1d, - NR1aC (O) NR1bR1c, -NR1aC (>； = NR1d) NR1bR1c, -NR1aS (O) R1d, -NR1aS (O) 2R1d, - NR1aS (O) NR1bR1c, -NR1a (ONR1a) ) 2NR1bR1c, -SR1a, -S (O) R1a, -S (O) 2R1a, -S (O) NR1bR1c, oS (O) 2NR1bR1c； wherein each R1a, R1b, R1c, and R1d is independently (i) hydrogen； (ii) C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C3-10 cycloalkyl, C6-14 aryl, C7-15 aralkyl, heteroaryl, or heterocyclyl； or (iii) R1b and R1c together with the N atom to which they are attached form the heterocyclyl； R3 and R4 are each independently hydrogen or C1-6 alkyl； or R3 and R4 join together to form a bond, C1-6 alkylene, C1-6 heteroalkylene, C2-6 alkenylene, or C2-6 heteroalkenylene； R5a is hydrogen or C1-6 alkyl； R5b is C1-6 alkyl or -C (O) OR1a； R5c is - (CR5fR5g) n- (C6-14 aryl) or - (CR5fR5g) n-heteroaryl； R5f and R5g are each independently (a) hydrogen or halo； (b) C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C3-10 cycloalkyl, C6-14 aryl, C7-15 aralkyl, heteroaryl, or heterocyclyl； or (c) -C (O) R1a, -C (O) OR1a, - C (O) NR1bR1c, -C (NR1a) NR1bR1c, -OR1a, -OC (O) R1a, - OC (O) OR1a, - OC (O) NR1bR1c, -OC (>； = NR1a) NR1bR1c, - OS (O) R1a, -OS (O) 2R'a, -OS (O) NR1bR1c, -OS (O) 2NR1bR1c, -NR1b
