A compound of Formula I: ** Formula ** or an enantiomer, a mixture of enantiomers, a mixture of two or more diastereomers, a tautomer, or a mixture of two or more tautomers thereof； or a pharmaceutically acceptable salt, solvate or hydrate thereof； wherein: each of R1, R2, R3, R4 and R5 is independently hydrogen, halo or C1-6 alkyl； wherein two of R1, R2, R3, R4 and R5 are halo or C1-6 alkyl, and the remaining three are hydrogen； R6 is cyano or nitro； R7 is (a) halo, cyano, nitro, oxo or guanidine； (b) C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C3-7 cycloalkyl, C6-14 aryl, C7-15 aralkyl, heteroaryl or heterocyclyl； or (c) -C (O) R1a, - C (O) OR1a, -C (O) NR1bR1c, -C (NR1a) NR1bR1c, -OR1a, - OC (O) R1a, -OC (O) OR1a, - OC (O) NR1bR1c, -OC (>； = NR1a) NR1bR1c, -OS (O) R1a, -OS (O) 2R1a, -OS (O) NR1bR1c, - OS (O) 2NR1bR1c, -NR1bR1c, -NR1aC (O ) R1a, -NR1aC (O) OR1d, -NR1aC (O) NR1bR1c, -NR1aC (>； = NR1d) NR1bR1c, - NR1aS (O) R1d, -NR1aS (O) 2R1d, -NR1aS (O) NR1bR1c, -N (NR1bR1c) O) 2NR1bR1c, -SR1a, -S (O) R1a, -S (O) 2R1a, -S (O) NR1bR1c, or -S (O) 2NR1bR1c X is O or S； RYa is -C (O) R1a, with the proviso that RYa is not -C (O) H； m is 1； n is 1； p is 0； and each R1a, R1b, R1c and R1d is independently hydrogen, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C3-7 cycloalkyl, C6-14 aryl, heteroaryl or heterocyclyl； or each pair of R1b and R1c together with the N atom to which they are attached independently form heteroaryl or heterocyclyl； wherein each alkyl, alkenyl, alkynyl, cycloalkyl, aryl, aralkyl, heterocyclyl and heteroaryl optionally is substituted with one or more groups, each independently selected from (a) cyano, halo and nitro； (b) C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C3-7 cycloalkyl, C6-14 aryl, C7-15 aralkyl, heteroaryl and heterocyclyl, each optionally substituted with one or more, in one embodiment, one, two, three or four substituents Q； and (c) -C (O) Ra, -C (O) ORa, -C (O) NRbRc, -C (NRa) NRbRc, -ORa, -OC (O) Ra, -OC (O) ORa, - OC (O) NRbRc, - OC (>； =
