Heterocyclic Derivatives of substituted benzamides, Pharmaceutical compositions containing them and their use in treating Pain, diabetes, Obesity and other Neurological Diseases
Claim 1: substituted benzamide Compound of the General formula (1), where a represents 0 OR 1； T represents 1, 2 or 3； b represents 0, 1 or 2； c and D are independent of each other, respectively, represent 0,1 or 2 with the condition that the elements of the Ring Cycle contain 7 maximum； X represents N (r9a) or C (r9b)； D (H) represents one of The residue formula (D1) and (D2)； Q represents 0 OR 1； s is 0 OR 1； R represents 1, 2 or 3； b represents C (= o) (OR = 2 S) and Group C (= o) - N (R10), Where The residue is attached to the nitrogen Atom, R1, Q1 and Q2, independent of each other, represent CCH o n respectively； r1 represents alkyl, aryl, heteroaryl C1 - 9, CH (aryl) 2 - 8 heterociclilo C3, cycloalkyl, aryl or heteroaryl, represent a, CH (aryl) 2 - 8 C3, cycloalkyl or heterociclilo United by an alkyl group 6 Group C1, C2 alquenilo - 6 - 6 alquinilo C2 or a Group； R2 repr You have C1 - 6 h, alkyl, cycloalkyl, aryl, heteroaryl heterociclilo, 8, orRepresents a C3 - 8 heterociclilo cycloalkyl, aryl or heteroaryl, joined by a group alquileno C1 - 6； R3 and R4 with the Group - Q1 - Q2 - which together form a Cycle, which can not be replaced or substituted banding, in one or several, for example, 1 2 or 3 elements of Nillo carbon with one or more, for example, 1, 2, 3 or 4 substituents are independent of each otherSelected from the group consisting of F, CL, BR, I, CF3, C1 - 6 alkyl, o-alkyl C1 - 6, Oh, ocf3, sh, scf3, aryl and heteroaryl and / or at least one, for example, 1 or 2, aryl or heteroaryl, where the cycle is saturated, single or multiple, for example, once or twice, Not saturated or Aromatic, has 4 -, 5 -, 6 - or 7 - Elements, and may contain in each caseOne or more, for example, 1, 2, or 3, heteroatoms heteroatoms or groups of mutually Independent, selected from the group consisting of N, nr11, o, S, S (= o) and S (= o) 2； Where The residue R11 is H, alkyl C1 - 6 C (= o) - 8 pp. ISBN R12, cycloalkyl, aryl, heteroaryl or signif C3 - 8 ica a cycloalkyl, a
