CANALES, EDA,CHONG, LEE S.,CLARKE, MICHAEL O'NEIL HANRAHAN,DOERFFLER, EDWARD,LAZERWITH, SCOTT E.,LEW, WILLARD,MERTZMAN, MICHAEL,MORGANELLI, PHILIP ANTHONY,WATKINS, WILLIAM J.
申请号：
ES11701588
公开号：
ES2543105T3
申请日:
2011.01.14
申请国别(地区):
ES
年份:
2015
代理人:
摘要：
A compound of Formula I: ** Formula ** or a pharmaceutically acceptable salt thereof, wherein: R1 is selected from the group consisting of optionally substituted C1-12 alkyl, optionally substituted C2-12 alkenyl, C2- alkynyl 12 optionally substituted, optionally substituted C3-12 cycloalkyl, optionally substituted C6-14 aryl, optionally substituted 3-14 heteroaryl, optionally substituted 3-12 heterocyclyl, optionally substituted 3-18 heteroarylalkyl, 3-18 heterocyclyl alkyl optionally substituted members and optionally substituted C6-18 arylalkyl, wherein each substituted R1 is substituted with one or more Q1； each Q1 is independently selected from the group consisting of halogen, oxo, oxide, -NO2, -N (>； = O), - SR10, -S (O) R10, -S (O) 2R10, -S (O ) 2NR10R11, -NR10C (O) R11, -NR10CONR11R12, -NR10S (O) R11, -NR10OS (O) 2R1, OP (O) R11R12, -P (O) R11R12, -P (O) OR11R12, -P ( O) (OR11) OR12, -C (O) NR11R12, optionally substituted C1-6 alkyl, optionally substituted C2-6 alkenyl, optionally substituted C2-6 alkynyl, optionally substituted C3-6 cycloalkyl, optionally substituted C6-12 arylalkyl, aryl Optionally substituted C6-12, optionally substituted 3-14 membered heteroaryl, optionally substituted C1-6 alkyloxy, optionally substituted C2-6 alkenyloxy, optionally substituted C2-6 alkynyloxy, optionally substituted C3-6 cycloalkyloxy, optionally substituted C6-12 aryloxy, optionally substituted 3-14 membered heteroaryloxy, optionally substituted 4-12 membered heterocyclyloxy, -C (O) optionally substituted C1-6 alkyl, -C (O) optionally C2-6 alkenyl optionally substituted, -C (O) optionally substituted C2-6 alkynyl, -C (O) optionally substituted C3-6 cycloalkyl, -C (O) optionally substituted C6-12 aryl, -C (O) -3-14 member heteroaryl optionally substituted, -C (O) optionally substituted C6-12 arylalkyl, optionally substituted 3-10 membered heterocyclyl, -OH, -NR11R12, -C (O) OR10, -CN, -N3, -C (>； = NR13) NR11R12, -C (>； = NR13) OR10, -NR10C (>； = NR13) NR11R12,
