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Flaviviridae virus inhibitors
- 专利权人:
- Gilead Sciences; Inc.
- 发明人:
- CANALES, Eda,CLARKE, Michael,LAZERWITH, Scott,LEW, Willard,MORGANELLI, Philip,WATKINS, William
- 申请号：
- ES11700988
- 公开号：
- ES2626150T3
- 申请日:
- 2011.01.14
- 申请国别(地区):
- ES
- 年份:
- 2017
- 代理人:
- 摘要：
- A compound of Formula I: ** Formula ** or a pharmaceutically acceptable salt thereof, wherein: R2 is selected from the group consisting of ** Formula ** Het is an optionally substituted 3-12 membered heterocyclyl or heteroaryl 3-14 optionally substituted members； wherein, each substituted Het is substituted with one or more Q4； each Q4, independently, is selected from the group consisting of halogen, oxo, oxide, -NO2, - N (>； = O), -SR40, -S (O) R40, -S (O) 2R40, -S (O) 2NR40R41, -NR40C (O) R41, -NR40C (O) NR4115 R42, -NR40S (O) R41, - NR40S (O) 2R41, -OP (O) R41R42, -P (O) R41R42, -P (O) OR41R42, -P (O) (OR41) OR42, -C (O) NR41R42, optionally substituted C1-6 alkyl, optionally substituted C2-6 alkenyl, optionally substituted C2-6 alkynyl, optionally substituted C3-6 cycloalkyl, optionally substituted C6-12 arylalkyl, optionally substituted C6-12 aryl, optionally substituted 3-14 membered heteroaryl, optionally substituted C1-6 alkyloxy, optionally substituted C2-6 alkenyloxy, optionally substituted C2-6 alkyloxy, optionally substituted C3-6 alkyloxy , optionally substituted C6-12 aryloxy, optionally substituted 3-14 membered heteroaryloxy, optionally substituted 4-12 membered heterocyclyloxy, -C (O) optionally substituted C1-6 alkyl, -C (O) optional C2-6 alkenyl optionally substituted, -C (O) optionally substituted C2-6 alkynyl, -C (O) -C3-6 optionally substituted C3-6cycloalkyl, -C (O) optionally substituted C6-12 aryl, -C (O) -3- heteroaryl 14 optionally substituted members, -C (O) optionally substituted C6-12 arylalkyl, optionally substituted 3-10 heterocyclyl, -OH, -NR41R42, -C (O) OR40, -CN, -N3, -C (>； = NR43) NR41R42, -C (>； = NR43) OR40, - NR40C (>； = NR43) NR41R42, -NR41C (O) OR40 and -OC (O) NR41R42； each R40, R41 and R42 is independently selected from the group consisting of H, optionally substituted C1-12 alkyl, optionally substituted C2-12 alkenyl, optionally substituted C2-12 alkynyl, optionally substituted C3-12 cycloalkyl, C6-14 aryl optiona
- 来源网站：
- 中国工程科技知识中心
- 来源网址：
- http://www.ckcest.cn/home/
