N-substituted oxazinopteridines and N-substituted oxazinopteridinones

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专利权人:

TAKEDA PHARMACEUTICAL COMPANY LIMITED

发明人:

CHANG, EDCON,GIBSON, TONY,JIN, BOHAN,SCORAH, NICHOLAS,DONG, QING

申请号：

ES12716773

公开号：

ES2533042T3

申请日:

2012.02.24

申请国别(地区):

ES

年份:

2015

代理人:

摘要：

A compound of Formula 1 ** Formula ** or a pharmaceutically acceptable salt thereof, wherein: G1 is selected from N and CR7； G2 is selected from C>； = O and CH2； Ar is selected from C6-14 aryl and C1-10 heteroaryl； m is 0, 1, 2, 3 or 4； n is 0.1, 2 or 3； each R1 is independently selected from cyano, halo, hydroxy, nitro, oxo, optionally substituted C1-6 alkyl, optionally substituted C1-4 alkoxy, optionally substituted C2-4 alkenyl, optionally substituted C2-4 alkynyl, optionally substituted C3-8 cycloalkyl , optionally substituted C3-6 heterocyclyl, optionally substituted C6-14 aryl, optionally substituted C6-14 aryloxy, optionally substituted C1-10 heteroaryl, optionally substituted C1-10 heteroaryloxy, -C (O) OR4, -OC (O) R4, -N (R4) R5, -NHC (O) N (R8) R9, -S (O) 2R6, - S (O) 2N (R4) R5, -C (O) N (R8) R9, -NHC ( O) OR10, -NHS (O) 2NHR8, -NHS (O) 2R6, -NHC (O) NHN (R8) R9, -NHC (S) N (R8) R9, - NHC (>； = NR11) N (R8 ) R9, -NHC (SR12) N (R8) R9 and -NHC (>； = NR11) OR13； R2 is selected from hydrogen, cyano, halo, hydroxy, nitro, optionally substituted C1-6 alkyl, optionally substituted C1-4 alkoxy, optionally substituted C2-4 alkenyl, optionally substituted C2-4 alkynyl, optionally substituted C3-6 heterocyclyl, aryl Optionally substituted C6-14, optionally substituted C6-14 aryloxy, optionally substituted C1-10 heteroaryl, -C (O) OR4, -OC (O) R4, -N (R4) R5 and -S (O) 2R6； R3 is selected from hydrogen, optionally substituted C1-6 alkyl, optionally substituted C3-8 cycloalkyl, optionally substituted C3-6 heterocyclyl, optionally substituted C6-14 aryl, optionally substituted C1-10 heteroaryl, - (CH2) nN (R4) R5 , - (CH2) nC (O) N (R4) R5 and -S (O) 2R6； each R4 and R525 is independently selected from hydrogen, optionally substituted C1-6 alkyl, optionally substituted C3-8 cycloalkyl, optionally substituted phenyl, optionally substituted C3-6 heterocyclyl and optionally substituted C1-10 heteroaryl； each R6 is independently selected from optionally substituted

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