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Benzimidazole derivatives as EP4 ligands
专利权人:
Bayer Pharma Aktiengesellschaft
发明人:
PETERS, Olaf,BRÄUER, Nico,BOTHE, Ulrich,KOPPITZ, Marcus,NAGEL, Jens,LANGER, Gernot
申请号:
ES14814837
公开号:
ES2651857T3
申请日:
2014.12.16
申请国别(地区):
ES
年份:
2018
代理人:
摘要:
Compounds of the general formula (I) ** Formula ** in which A represents hydrogen, bromine, cyano, formyl, C1-C3 alkyl, 4-6 membered heterocyclyl, 5-6 membered heteroaryl, R11O-C (>; = O) - (CH2) p-, R5R5'NC (>; = O) - (CH2) p-, R11O-S (>; = O) 2- (CH2) p-, R5R5'NS (>; = O) 2 - (CH2) p-, (C1-C6 alkyl) -S (>; = O) 2-, (C1-C6 alkyl) -S (>; = O) (>; = NH) - or (C3-C6 cycloalkyl) - S (>; = O) (>; = NH) -, wherein the heteroaryl is preferably selected from the group consisting of pyrazolyl, imidazolyl, triazolyl, tetrazolyl, oxazolyl, isoxazolyl and oxadiazolyl, and where the alkyl radicals may be the case mono - or polysubstituted, the same or different, with halogen or hydroxy, and where the heterocyclyl radicals may be the case mono- or polysubstituted, the same or different, with C1-C3 alkyl, trifluoromethyl or hydroxy, and where the heteroaryl radicals can if mono- or polysubstituted, the same or different, with C1-C3 alkyl, trifluoromethyl or hydroxy, B is selected from the following s structures, ** Formula ** where * means the binding site in the molecule, R1a, R1b independently represent hydrogen, cyano, C1-C5 alkyl, C2-C5 alkenyl, C2-C5 alkynyl, (cycloalkyl C3-C6) - (CH2) m-, (4-6 membered heterocyclyl) - (CH2) n-, (C1-C5 alkoxy) - (C1-C3 alkyl) -, (C3-C6 cycloalkoxy) - (alkyl C1-C3) -, H2N- (C1-C3 alkyl) -, (C1-C5 alkyl) NH- (C1-C3 alkyl) - or (C1-C5 alkyl) 2N- (C1-C3 alkyl) -, where the heterocyclyl is preferably selected from the group consisting of oxetanyl, tetrahydrofuranyl, tetrahydropyranyl, 1,4-dioxanyl, morpholinyl, azetidinyl, pyrrolidinyl, piperazinyl and piperidinyl, and where the alkyl radicals, cycloalkyl radicals and heterocyclyl radicals may be the case mono - or polysubstituted, the same or different, with halogen, C1-C5 alkyl, hydroxy, C (>; = O) OH, HO-C (>; = O) - (C1-C5 alkyl) -, (C1-C5 alkyl) OC (>; = O) - (C1-C5 alkyl) - or (C1-C5 alkyl) -S (>; = O) 2-, R4 represents hydrogen, fluorine, chlorine, C1- alkyl C2, C
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