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Imidazole compounds condensed with aryl or heteroaryl as intermediates for anti-inflammatory and analgesic agents
- 专利权人:
- RAQUALIA PHARMA INC
- 发明人:
- NAKAO, KAZUNARI,OKUMURA, YOSHIYUKI,MATSUMIZU, MIYAKO,UNEO, NAOMI,HASHIZUME, YOSHINOBU,KATO, TOMOKI,KAWAI, AKIYOSHI,MIYAKE, YORIKO,NUKUI, SEIJI,SHINJYO, KATSUHIRO,TANIGUCHI, KANA
- 申请号：
- ES06110920
- 公开号：
- ES2524586T3
- 申请日:
- 2001.10.15
- 申请国别(地区):
- ES
- 年份:
- 2014
- 代理人:
- 摘要：
- A compound, which is a compound of formula (II) or a salt thereof: ** Formula ** in which each of Y1, Y2, Y3 and Y4 is independently N, CH or C (L)； R1 is H, C2-8 alkyl, C2-8 alkenyl, C2-8 alkynyl, C3-7 cycloalkyl, C1-8 alkoxy, halo- substituted C1-8 alkoxy, C1-8-S (O) alkyl-, Q1 -, amino, mono- or di- (C1-8 alkyl) amino, (C1-4 alkyl) -C (>； = O) -N (R3) - or (C1-4 alkyl) -S (O) mN ( R3) -, wherein said C1-8 alkyl, C2-8 alkenyl and C2-8 alkynyl are optionally substituted with halo, C1-3 alkyl, C1-4 alkoxy-, (C1-4 alkyl) -S (O) m-, C3-7- cycloalkyl, cyano, indanyl, 1,2,3,4-tetrahydronaphthyl, 1,2-dihydronaphthyl, Q1-, Q1-C (>； = O) -, Q1-O-, Q1-S (O) m-, Q1- (C1-4 alkyl) -O-, Q1- (C1-4 alkyl) -S (O) m-, Q1- (C1-4 alkyl) -C (O) -N ( R3) -, Q1- (C1-4 alkyl) -N (R3) - or (C1-4 alkyl) -C (O) -N (R3) -； Q1 is a 5-12 membered monocyclic or bicyclic aromatic ring that optionally contains up to 4 heteroatoms selected from O, N and S, and is optionally substituted with halo, C1-4 alkyl, halo substituted C1-4 alkyl, hydroxy, alkoxy C1-4, halo-substituted C1-4 alkoxy, C1-4 alkylthio, nitro, amino, mono- or di- (C1-4 alkyl) amino, cyano, C1-4 hydroxyalkyl, C1-4 alkoxy- (C1- alkyl 4), C1-4 alkyl sulfonyl, aminosulfonyl, C1-4 alkyl (>； = O) -, HO-C (>； = O) -, (C1-4 alkyl) -OC (>； = O) -, R3N (R4) C (>； = O) -, C1-4 alkylsulfonylamino, C3-7 cycloalkyl, R3C (>； = O) N (R4) - or NH2-C (>； = NH) -； A is a benzene ring optionally substituted with up to 3 substituents or a pyridine ring optionally substituted with up to 3 substituents selected from halo, C1-4 alkyl, halo substituted C1-4 alkyl, hydroxy, C1-4 alkoxy, C1- alkoxy 4 halo-substituted, C 1-4 alkylthio, nitro, amino, mono- or di- (C 1-4 alkyl) amino, cyano, C 1-4 hydroxyalkyl, (C 1-4 alkoxy) -C 1-4 alkyl, C 1-4 alkylsulfonyl , aminosulfonyl, acetyl, R3N (R4) C (>； = O) -, HO-C (>； = O) -, (C1-4 alkyl) -OC (>； = O) -, C1-4 alkylsulfonylamino, C3 cycloalkyl 7, R3C (>； = O) -N (R4) - and NH2-C (>； = NH)
- 来源网站：
- 中国工程科技知识中心
- 来源网址：
- http://www.ckcest.cn/home/
