SWIDORSKI JACOB,MEANWELL NICHOLAS A.,SIT SING,YUEN - SIN NY,VENABLES BRIAN LEE,CHEN YAN,CHEN JIE,REGUEIRO-REN ALICIA,LIU ZHENG
申请号：
ARP120100314
公开号：
AR085053A1
申请日:
2012.01.31
申请国别(地区):
AR
年份:
2013
代理人:
摘要：
Claim 1: a Compound, which includes pharmaceutically acceptable salts of this, wherein is selected from the group consisting of: a compound of the formula (1), a compound of the formula (2)； and a compound of the formula (3), where R1 is isopropenilo or isopropyl； J and E - H OR - CH3,And E is absent when the double bond is present； X is a substituted phenyl or heteroaryl ring a, where a is at least one member selected from the group of - H, - Halo - hydroxyl, alkyl, alkoxy C1 C1 - 6, - 6 and - coor2； R2 is - C1 - 6 h, alkyl, alkyl substituted with alkyl C1 - 6 Alkyl or aryl - substituted with C1 - 6； and is selected from the group of coor2 -, - C (o) nr2so2r3,Nhso2nr2r2, - C (o) - nr2so2r2, so2nr2r2, cicloalquil - - 6 - - coor2 C3, C2 coor2 alquenil - 6 - - - 6 - coor2 alquinil C2, C1 - alkyl - 6 - coor2, NHC (o) - (CH2) - N - coor2, so2nr2c (or R2), - tetrazol and conhoh, where n = 1 - 6； R3 is alkyl or alkyl C1 C1 - 6 - 6 substituted with alkyl； R4 is selected from the group of - H, - Alkyl alkyl C1 C1 - 6, 6 - (2 - (OR3) cycloalkyl alkyl C1 - C3 - 6, 6 - substitutedCycloalkyl alkyl - C1 - C3 - 6 - 6, 6 - Q1 - C1 - alkyl, alkyl - C1 - C3 - 6 - 6 - cicloalquil Q1, aryl, heteroaryl heteroaryl substituted, cor6 cocor6, -, -, - and - so2r7, so2nr2r2, a group of formulas where (4)； Q1 is selected from the group of halogen substituted heteroaryl heteroaryl,,, - CF3, OR2, - coor2 nr8r9 -, - and - conr10r11 so2r7； R5 is selected from the group of H, alkyl C1 - 6Cycloalkyl - C1 - C3 - 6, 6 - alkyl substituted alkyl, alkyl - C1 - 6 - nr8r9 cor10 cor6 -, -, -, - and - cocor6, so2r7 so2nr2r2； whenever only one of R4 or R5 can be selected from the group of cor6 cocor6 -, -, - and - so2r7 so2nr2r2； or R4 and R5 are taken jointly with the adjacent one to form a rest Or formula (5)； R6 is selected from the group of H, alkyl C1 - 66 - alkyl - substituted C1 - C3 alkyl, cycloalkyl - 6 - 6 pp. ISBN cycloalkyl substituted with alkyl - Q2, C1 - Q2 - 6, 6 - alkyl substituted with alky
