A pharmaceutical product for lowering blood LDL, which is a pharmaceutical product that contains a compound represented by formula (I) as an active ingredient, said compound having actions of inhibiting the expression of PCSK9mRNA, lowering the amount of PCSK9 protein, and increasing the amount of an LDL receptor. (In formula (I), R1 represents a hydrogen atom, a hydroxyl group, a C1-6 alkoxy group or the like； R represents a C1-6 alkyl group or the like； the ring structure Q represents a phenyl group or a monocyclic or bicyclic heterocyclic ring； and each of R2 and R3 represents a hydrogen atom, a C1-6 alkyl group, a C2-6 alkenyl group, a C3-8 cycloalkyl C1-6 alkyl group or the like.).一種醫藥，其係降低血中LDL之醫藥，且含有具有抑制PCSK9 mRNA之表現，降低PCSK9蛋白量，增加LDL受體量之作用的式(I)(R1表示氫原子、羥基、C1-6烷氧基等，R表示C1-6烷基等，式(I)中，Q表示之環構造係表示苯基或單環性或二環性之雜環，R2、及R3表示氫原子、C1-6烷基、C2-6烯基、C3-8環烷基C1-6烷基等)表示之化合物，作為有效成分。
