PURPOSE: A granule composition with improved solubility and flowability for vitamin complex is provided to enhance ubidecarenon solubility, thereby improving bioavailability and manufacturing a tablet with fat soluble vitamin. CONSTITUTION: A granule composition with improved solubility and flowability for vitamin complex contains 5-10 parts by weight of ubidecarenon, 5-50 parts by weight of poloxamer 407, 0.1-10 parts by weight of fat soluble vitamin selected among vitamin A, D, and E, and 10-200 parts by weight of an adsorption excipient. The granule composition further contains 10-50 parts by weight of omega-3. A method for manufacturing the granule composition comprises the steps of: dissolving fat soluble vitamin, ubidecarenon, and poloxamer 407； adding 10-100 parts by weight of ethanol and uniformly dissolving the mixture； adding the adsorption excipient and adsorbing the mixture； drying the adsorbed mixture； and allowing the adsorbed mixture through a sieve and forming granules.본 발명은 유비데카레논 및 지용성 비타민을 이용한 비타민 복합제용 가용성 및 흐름성을 개선한 과립 조성물 및 이의 제조방법에 관한 것이다.본 발명은 유비데카레논 5 ∼ 10 중량부, 폴록사머 407 5 ∼ 50 중량부, 비타민 A, D 및 E로 이루어지는 군에서 선택된 유효량의 지용성 비타민 0.1 ∼ 10 중량부 및 흡착 부형제 10 ∼ 200 중량부로 이루어지는 비타민 복합제용 가용성 및 흐름성을 개선한 과립 조성물과 이의 제조방법을 제공한다.
