DODD STEPHANIE KAY,FURET PASCAL,GROTZFELD ROBERT MARTIN,JONES DARRYL BRYNLEY,MANLEY PAUL,MARZINZIK ANDREAS,PELLE XAVIER FRANCOIS ANDRE,SALEM BAHAA,SCHOEPFER JOSEPH
申请号:
TN2014000427
公开号:
TN2014000427A1
申请日:
2014.10.13
申请国别(地区):
TN
年份:
2016
代理人:
摘要:
The present invention relates to compounds of formula (I): in which Y, Y1, R1, R2, R3 and R4 are defined in the Summary of the Invention; capable of inhibiting the activity of BCR-ABL1 and mutants thereof. The invention further provides a process for the preparation of compounds of the invention, pharmaceutical preparations comprising such compounds and methods of using such compounds in the treatment of cancers.