DODD, Stephanie Kay,FURET, Pascal,GROTZFELD, Robert Martin,JONES, Darryl Brynley,MANLEY, Paul,MARZINZIK, Andreas,PELLE, Xavier Francois Andre,SALEM, Bahaa,SCHOEPFER, Joseph,JAHNKE, Wolfgang
申请号:
DK13730652
公开号:
DK2861579T3
申请日:
2013.05.09
申请国别(地区):
DK
年份:
2018
代理人:
摘要:
The present invention relates to compounds of formula (I): in which Y, Y1, R1, R2, R3 and R4 are defined in the Summary of the Invention; capable of inhibiting the activity of BCR-ABL1 and mutants thereof. The invention further provides a process for the preparation of compounds of the invention, pharmaceutical preparations comprising such compounds and methods of using such compounds in the treatment of cancers.