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Imidazo-oxadiazole and imidazo-thiadiazole derivatives
专利权人:
Ares Trading SA
发明人:
QUATTROPANI, Anna,SWINNEN, Dominique
申请号:
ES13724172
公开号:
ES2582556T3
申请日:
2013.05.23
申请国别(地区):
ES
年份:
2016
代理人:
摘要:
Compound of formula (I) ** Formula ** in which X indicates O or S, U is selected from (i) a phenyl ring which may be substituted with 1 or 2 groups independently selected from C1-C6 alkoxy, C1 alkyl -C6, halogen, CN (ii) a 5 or 6 membered unsaturated or aromatic heterocyclic system comprising 1 nitrogen atom and optionally up to 2 additional heteroatoms independently selected from N, O or S, which may be substituted with 1 or 2 groups independently selected from C1-C6 alkoxy, C1-C6 alkyl, halogen, CN, (iii) a single bond. T indicates -NR5-, -NR5CO-, -CONR5, -NR5-CO-NR5, -CO W is selected from (i) a linear or branched C1-C6 alkylene in which 1 to 2 H atoms can be replaced by a phenyl, halogen, CN, CF3 ring, (ii) a linear or branched C1-C6 alkylene in which 1 CH2 group is replaced by a 3 to 7 membered saturated carbocyclic ring, (iii) a linear C1-C6 alkylene or branched in which 1 CH2 group is replaced by - a phenyl ring optionally fused to the phenyl ring A, - a saturated 5- or 6-membered heterocyclic system containing 1 or 2 nitrogen atoms, or - an aromatic heterocyclic system 5-member containing 1 to 3 heteroatoms independently selected from N, O and S, and optionally condensed with a saturated 6-membered carbocyclic ring, or optionally condensed with the phenyl ring A, - and in which another CH2 group which is not bound to T is optionally replaced by -O- or NR5, (iv) a single bond, R5 is H or a linear or branched C1-C6 alkyl, R1 indicates a linear or branched alkyl having 1 to 6 carbon atoms, Ra 30 indicates H, CN, halogen, a linear or branched alkyl having 1 to 6 carbon atoms, wherein from 1 to 3 H atoms can be replaced by halogens, linear or branched alkoxy having 1 to 6 carbon atoms, in which 1 to 3 H atoms can be replaced by halogens,Compuesto de fórmula (I)**Fórmula** en la que X indica O o S, U se selecciona de (i) un anillo de fenilo que puede estar sustituido con 1 ó 2 grupos seleccionados independientemente de alcoxilo C1-C6, alquilo C1-C6, halógeno, CN (
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