A continuous arcyclic compound represented by the formula: ** Formula ** wherein Alk represents a linear C1-6 alkylene group, a branched C1-6 alkylene group or a C1-6 alkylene group having a ring structure； wherein a part of the carbon atoms constituting the ring structure may be optionally substituted by an oxygen atom, a nitrogen atom or a sulfur atom, in the ring X, X1 represents N or CRX1, X2 represents N or CRX2, X3 represents N or CRX3, X4 represents N or CRX4, in which RX1, RX2, RX3 and RX4 each independently represent a hydrogen atom； a linear or branched C1-6 alkyl group which may be substituted with a halogen atom (s)； a C3-7 alkyl group having a ring structure that may be substituted with a halogen atom (s)； a linear or branched C1-6 alkoxy group； a halogen atom or a cyano group, in the ring Y, Y1 represents N or CRY1, Y2 represents N or CRY2, Y3 represents N or CRY3, Y4 represents N or CRY4, RY1, RY2, RY3 and RY4 each independently represent a hydrogen atom； a linear or branched C1-6 alkyl group which may be substituted with a halogen atom (s)； a C3-7 alkyl group having a ring structure that may be substituted with a halogen atom (s)； a linear or branched C1-6 alkoxy group； a halogen atom or a cyano group, in the Z ring, RZ represents a linear or branched C1-6 alkyl group that may be substituted with a halogen atom (s) or C3-7 alkyl group having a structure ring which may be substituted with a halogen atom (s), or pharmaceutically acceptable salt thereof.Un compuesto aricíclico continuo representado por la fórmula:**Fórmula** en la que Alk representa un grupo alquileno C1-6 lineal, un grupo alquileno C1-6 ramificado o un grupo alquileno C1-6 que tiene una estructura de anillo； en la que una parte de los átomos de carbono que constituyen la estructura de anillo pueden estar opcionalmente sustituidos por un átomo de oxígeno, un átomo de nitrógeno o un átomo de azufre, en el anillo X, X1 representa N o CRX1, X2 representa N o CRX2, X3 representa N o CRX3, X
