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Vitamin D derivatives active in vitamin D nuclear receptors, preparation and uses thereof
专利权人:
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE;UNIVERSIDAD DE SANTIAGO DE COMPOSTELA;INSERM (INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE);UNIVERSITE DE STRASBOURG;UNIVERSITE DE STRASBOURG
发明人:
MORAS, DINO,MOURINO-MOSQUERA, ANTONIO,RODRIGUES, LUIS CEZAR,ROCHEL, NATACHA,WURTZ, JEAN-MARIE
申请号:
ES06793841
公开号:
ES2378895T3
申请日:
2006.09.26
申请国别(地区):
ES
年份:
2012
代理人:
摘要:
A compound having the following formula (I): wherein R1 represents a group selected from a hydrogen atom, a linear or branched (C1-C10) alkyl and a (C1-C10) alkoxy, wherein said group is optionally substituted with at least one hydroxyl group; and in which R represents where Z represents in which: - R2 and R3, identical or different, represent a group selected from H, a halogen atom, a branched or linear C1-C10 alkyl group, branched C2-C10 alkenyl linear or branched or linear C2-C10 alkynyl; - R4 and R5, identical or different, represent a group selected from H, a halogen atom, a linear or branched C1-C6 alkyl group, branched or linear C2-C10 alkenyl or branched or linear C2-C10 alkynyl; - m represents an integer between 0 and 5 inclusive; and - n represents an integer between 0 and 5 inclusive, said alkenyl group being optionally substituted with an aryl group; said alkynyl group being optionally substituted with an aryl group or said alkynyl group being selected alternatively from the 3- (benzyloxy) -prop-1-inyl and tert-butyl-prop-2-inylcarbamate groups; and where the term aryl includes any aromatic group comprising from 5 to 14 carbon atoms, optionally interrupted by one or more heteroatoms selected from N, O, S or P (called, more specifically, heteroaryl).Un compuesto que presenta la siguiente fórmula (I): en la que R1 representa un grupo seleccionado de un átomo de hidrógeno, un alquilo (C1-C10) lineal o ramificado y un alcoxi (C1-C10), donde dicho grupo está opcionalmente sustituido con al menos un grupo hidroxilo; y en la que R representa donde Z representa en la que: - R2 y R3, idénticos o diferentes, representan un grupo seleccionado de H, un átomo de halógeno, un grupo alquilo C1-C10 ramificado o lineal, alquenilo C2-C10 ramificado o lineal o alquinilo C2-C10 ramificado o lineal; - R4 y R5, idénticos o diferentes, representan un grupo seleccionado de H, un átomo de halógeno, un grupo alquilo C1-C6 lineal o ramificado, alquenilo C2-C10 ramificado o lineal
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