The General Hospital Corporation;Annovation Biopharma, Inc.
发明人:
RAINES, Douglas E.,HUSAIN, Syed Shaukat,RANDLE, John C.R.
申请号：
ES13735638
公开号：
ES2617536T3
申请日:
2013.01.11
申请国别(地区):
ES
年份:
2017
代理人:
摘要：
A compound having a structure of formula (IA): ** Formula ** in which R2 is optionally substituted C1-C10 alkyl； each R3 is independently halogen, CN, CF3, SR2, SOR2, SO2R2, OR2, CO2H, CO2R2, N (R2) 2, NHR2, NO2, or R2； Z is N； R4 and R5 are independently hydrogen, halogen, CN, CF3, SR2, SOR2, SO2R2, OR2, CO2H, CO2R2, N (R2) 2, NHR2, NO2, or R2； R9 and R10 are independently hydrogen, optionally substituted linear or branched C1-C10 alkyl, optionally substituted linear or branched C2-C10 alkenyl, optionally substituted linear or branched C2-C10 alkynyl, optionally substituted C4-C8 cyclyl, optionally substituted C3-C8 heterocyclyl , provided that at least one of R9 and R10 is not hydrogen, or R9 and R10 together with the carbon, are joined to form an optionally substituted 3-8 membered cyclyl or heterocyclyl； L2 is a bond, optionally substituted linear or branched C1-C10 alkylene, optionally substituted linear or branched C2-C10 alkenylene, or optionally substituted linear or branched C2-C10 alkynylene, wherein the C1-C10 alkylene structure, C2 alkenylene C10, or C2-C10 alkynylene optionally comprises one or more heteroatoms； T is H, a linear or branched C1-C10 alkyl, substituted or unsubstituted, linear or branched C2-C10 alkenyl, substituted or unsubstituted, linear or branched C2-C10 alkynyl, substituted or unsubstituted, optionally substituted cyclyl, optionally aryl substituted, or PEG, wherein the structure of C1-C10 alkyl, C2-C10 alkenyl, C2-C10 alkynyl optionally comprises one or more heteroatoms； and n is an integer from 0-5, or a salt, solvate, or ester thereof.Un compuesto que tiene una estructura de fórmula (IA): **Fórmula** en la que R2 es alquilo C1-C10 opcionalmente sustituido； cada R3 es independientemente halógeno, CN, CF3, SR2, SOR2, SO2R2, OR2, CO2H, CO2R2, N(R2)2, NHR2, NO2, o R2； Z es N； R4 y R5 son independientemente hidrógeno, halógeno, CN, CF3, SR2, SOR2, SO2R2, OR2, CO2H, CO2R2, N(R2)2, NHR2, NO2, o R2； R9 y R10 son independientemente hidróge
