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HETEROCYCLIC AMIDAS REPLACED, ITS PRODUCTION AND ITS USE.
专利权人:
ABBOTT GMBH & CO. KG
发明人:
LUBISCH, WILFRIED,MOELLER, ACHIM,TREIBER, HANS-JOERG,KNOPP, MONIKA
申请号:
ES06023149
公开号:
ES2373564T3
申请日:
1999.05.25
申请国别(地区):
ES
年份:
2012
代理人:
摘要:
Amides of general formula (I) and their tautomeric forms and their possible enantiomeric and diastereomeric forms, as well as possible physiologically acceptable salts, the variables having the following meaning: A means the condensed cycles of formulas B means phenyl and, R1 can mean hydrogen, C1-C6 alkyl, branched or unbranched, O-C1-C6 alkyl, branched or unbranched, C2-C6 alkenyl, C2-C6 alkynyl, C1-C6 alkyl-phenyl, C2-C6 alkenyl, C2-C6 alkynyl -phenyl, OH, Cl, F, Br, I, CF3, NO2, NH2, CN, COOH, COO-C1-C4 alkyl, -NHCO-C1-C4 alkyl, -NHCO-phenyl, CONHR11, -NHSO2-C1 alkyl -C4, - NHSO2-phenyl, -SO2-C1-C4 alkyl and -SO2-phenyl and R2 C1-C6 alkyl, branched or unbranched, which can carry a phenyl, cyclohexyl, pyridyl, thienyl, indolyl or naphthyl ring, which at the same time it can be substituted with a maximum of two residues R1, and R3 means CO-NR6R7 and R4 means hydrogen or (CH2) mNR8R9, O (CH2) mNR8R9 or and R5 means C1-C6 alkyl, line al or branched, and which may be substituted with a phenyl ring, which in turn may also be substituted with a maximum of two R10 moieties, and R6 means hydrogen, C1-C6 alkyl, branched or unbranched, and R7 means hydrogen, alkyl C1-C6, branched or unbranched, which may also be substituted 5 with a phenyl or pyridine ring, which may further carry an R10 moiety, or with and R8 means C1-C6 alkyl, linear or branched, and which may be substituted with a phenyl ring, which in turn may also be substituted with one or two radicals R10, and R9 means C1-C6 alkyl, linear or branched, and which may be substituted with a phenyl ring, which in turn may also be substituted with one or two residues R10, and R10 may mean hydrogen, C1-C4 alkyl, linear or branched, -O-C1-C4 alkyl, OH, Cl, F, Br, I, CF3, NO2, NH2, CN, CONH2, COOH , COO-C1-C4 alkyl, -NHCO-C1-C4 alkyl, -NHCO-phenyl, -NHSO2-C1-C4 alkyl, -NHSO2-phenyl, -SO2-C1-C4 alkyl and -SO2- phenyl and R11 hydrogen, C1-C6 alkyl, branched or unbranched, R15 hydrogen or the meaning of R8, m means a number 1,
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