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organic compounds
专利权人:
Novartis AG
发明人:
ADAMS, Christopher,HU, Qi-Ying,MCQUIRE, Leslie Wighton,PAPILLON, Julien
申请号:
ES09769310
公开号:
ES2654044T3
申请日:
2009.06.25
申请国别(地区):
ES
年份:
2018
代理人:
摘要:
A compound of Formula II: ** (See formula) ** in which: R2q is hydrogen or halogen; R3q is hydrogen, halogen, or cyano; R5q is hydrogen, alkyl, or cyano; R7q is alkoxy, -OSO2-heteroci-O-arylalkyl, -NR'-SO2-alkyl -NR'-C (O) -alkyl, -NR'-C (O) -NR'-alkyl, -NR'-C (O) - O-alkyl, haloalkyl, or alkyl optionally substituted with heterocyclyl, -NR'-SO2-alkyl, -NR'-SO2-haloalkyl, NR'-C (O) -alkyl, NR'-C (O) -heterocyclyl, -NR'-C (O) -NR'-alkyl, or -NR'-C (O) -O-alkyl; R 8q is hydrogen, alkyl, hydroxyalkyl, -alkyl-OC (O) -alkyl, carboxylate, alkoxycarbonyl, or alkyl substituted arylalkyl, or cyano-substituted alkyl and / or alkyl, or -alkyl-O-aryl substituted with alkoxycarbonyl; each R 'is independently hydrogen, C1-C4 alkyl, or C3-C6 cycloalkyl; and pharmaceutically acceptable salts thereof; with the proviso that when R5q is cyano, then at least one of R2q, R3q, and R8q is different from hydrogen; and wherein: the term "alkyl" represents C1-C4 alkyl; the term "alkoxy" represents alkyl, alkenyl, and alkynyl groups covalently linked to an oxygen atom; the term "alkenyl" represents -C2-C4 alkenyl; the term "alkynyl" represents -C2-C4 alkynyl; the term "heterocyclyl" represents an optionally substituted, saturated or unsaturated non-aromatic ring or an annular system, which is a monocyclic ring system of 4, 5, 6, or 7 members, bicyclic 7, 8, 9, 10, 11, or 12 members or tricyclic of 10, 11, 12, 13, 14 or 15 members and contains at least one heteroatom selected from O, S and N, where N and S can also be optionally oxidized in various oxidation states; the term "aryl" represents optionally substituted aromatic groups of a single 5- and 6-membered ring that may include zero to four heteroatoms; and the term "aroyl" represents an aryl attached to a carbonyl group.Un compuesto de Fórmula II: **(Ver fórmula)** en la que: R2q es hidrógeno o halógeno; R3q es hidrógeno, halógeno, o ciano; R5q es hidrógeno, alquilo, o ciano; R7q es alcoxi, -OSO2-heteroci-O-arilalquilo, -NR'-SO2-alquilo -N
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