JOHNSON RUSSELL,ZAHARIA CRISTIANA A.,CAI HAIYING,HU LILY W.,YANG HANBIAO,OSLOB JOHAN D.,EVANCHIK MARC,MDOWELL ROBERT S.
申请号：
ARP120100756
公开号：
AR086837A1
申请日:
2012.03.08
申请国别(地区):
AR
年份:
2014
代理人:
摘要：
Provided are compounds that are modulators of Fatty Acid Synthase. The compounds can be used to treat Disorders characterized by deregulation of the role of Fatty Acid Synthase through Modulation of the function and / or the Route of the Fatty Acid Synthase.Methods are provided for treating such Disorders that include Viral Infections, such as hepatitis C infection, cancer and Metabolic Disorders.Claim 1: The structure of a compound of formula (1) or a pharmaceutically acceptable salts thereof, wherein: R1 is H, halogen, alkyl of C1 - CN, - 4 - linear or branched, or - (cycloalkyl c3-5) - or - (c1-4 alkyl linear or branched) where opcionalmen cycloalkyl c3-5: It includes an oxygen or nitrogen Atom； and when R1 is H, cn or HalogenIs optionally substituted with one or more halogens； each R2 is independently Hydrogen, halogen, or linear or branched alkyl c1-4； R3 is - Oh or h, halogen； R21 is H, halogen, alkyl of C1 - 4 linear or branched, cycloalkyl c3-5 where cycloalkyl optionally c3-5 Inc Luye an atom of Oxygen or nitrogen； R22 is H, alkyl or Halogen C1 R24 is H, 2；C1-4 alkyl linear or branched (c1-4 alkyl, - t) - O - (c1-4 alkyl, cycloalkyl) T - OT - c3-5) or - (c1-4 alkyl (alkyl) - T or - C1 - 4 linear or branched), where t is 0: or 1； cycloalkyl c3-5 optionally includes an oxygen or nitrogen Atom； and N is CR23 L1； L2 is CH or N； at least one L1 or L2 is H OR N； and R23 is c1-4 alkyl linear or branched.Se proporcionan compuestos que son moduladores de la ácido graso sintasa. Los compuestos se pueden usar para tratar trastornos caracterizados por la desregulación de la función de la ácido graso sintasa por medio de la modulación de la función y/o la vía de la ácido graso sintasa. Se proporcionan métodos para tratar tales trastornos que incluyen infecciones virales, tales como infección por hepatitis C, cáncer y trastornos metabólicos.Reivindicación 1: Un compuesto de la estructura de fórmula (1), o una de sus sales farmacéuticamente aceptables, caracterizado porq
