BALINT, Balazs,CSEKEI, Marton,SZABO, Zoltan,KOTSCHY, Andras,CHANRION, Maia,GENESTE, Olivier,CHEN, I-Jen,DAVIDSON, James Edward Paul,SIPOS, Szabolcs,ONDI, Levente,PROSZENYAK, Agnes
申请号：
PE2017002717
公开号：
PE20181491A1
申请日:
2016.06.22
申请国别(地区):
PE
年份:
2018
代理人:
摘要：
Related to bicycle derivatives (I)Where: a represents (a) group,One of them is related to group W, two to phenyl ring； E is a floating ring, tienilo or pirrolilo； x1, X3, X4 and X5 are independent of each other, a carbon or nitrogen atom； X2 is a c-r21 or a nitration atom. R1 is a halogenated atom, a group of linear or branched substances of asphalt (C1-C6), a group of linear or branched substances of halogenated substances (C2-C6), and others； R2, R3, R4 and R5 are independent active atoms, halogenated, a group of linear or branched substances of asphalt (C1-C6), a group of linear or branched substances of aluminum (C2-C6), etc； R6 and R7 are independent of each other. They are a halogenated atom, a group of linear or branched asphalt (C1-C6),1. A linear or branched asphalt (C2-C6) group； W is - CH2 -,-NH-O oxygen atom； R8 is a hydrogen atom, a linear or branched atom of hydrocarbyl (C1-C8), an arilo group, etc.； R9 is a hydrogen atom, a linear or branched atom of hydrocarbyl group (C1-C6), an alquenio group (C2-C6),R10 is a hydrogen atom, a linear or branched hydrocarbon (C1-C6), an alquenio (C2-C6)； R14 is a hydrogen atom, a hydrogen Xi or a hydrogen group (C1-C6)；N is an integer equal to 0 or 1. It also mentions the preparation process of these compounds and the pharmacological components, including these compounds, which are used as agents to support apocalypse in the treatment of cancer and autoimmune diseases.Referido a compuestos derivados biciclicos de formula (I), en donde: A representa el grupo (a), en la que 1 esta unido al grupo W y 2 unido al anillo fenilo； E es un anillo furilo, tienilo o pirrolilo； X1, X3, X4 y X5 independientemente uno de otro, es un atomo de carbono o nitrogeno； X2 es C-R21 o un atomo de nitrogeno. R1 es un atomo de halogeno, un grupo alquilo(C1-C6) lineal o ramificado, un grupo alquenilo(C2-C6) lineal o ramificado, entre otros； R2, R3, R4 y R5 independientemente uno de otro, es un atomo de hidrogeno, halogeno, un grupo alquilo(C1-
