KIM, In Woo,YOO, Ja Kyung,KIM, Ji Duck,JUN, Sun Ah,LEE, Jun Hee
申请号：
PE2019001453
公开号：
PE20191715A1
申请日:
2018.03.19
申请国别(地区):
PE
年份:
2019
代理人:
摘要：
1. The compound referred to in the present invention is pyrrolidium zinc of chemical formula 1 or salt with acceptable efficacy, wherein: X is O, or NH； a is isoaromatics C6-10 ring, or isoaromatics C2-10 ring； R1 is h, or C1-4 asphalt is not replaced or replaced； R2 is hydrogen, C1-4 asphalt or halogen； R3 is a C1-4 tar, which is replaced by halogen and cyanogen. The preferred compounds are: n - (3 - ((2 - ((1-cyclop-1h-pirazol-4-il) amino) pirrolo [2, 1-f] [1, 2, 4] triazin-4-il) ox) - 4-fluorofenil) acrylamide； N - (3 - ((2 - ((4 -) (4 -) (4 -) (4-There are others These compounds are inhibitors of cinass JAK (Janus cinasa) and / or Btk (tirosin cinasa de Bruton).It is useful in the treatment or prevention of diseases such as flammability, autoimmunity, diffusion, cancer or tumor. He also mentioned composers who had these things in themLa presente invencion se refiere a compuestos derivados de pirrolotriazina de Formula Quimica 1 o una sal farmaceuticamente aceptable de los mismos, donde: X es O, o NH； A es un anillo aromatico C6-10 divalente, o un anillo heteroaromatico C2-10 divalente； R1 es H o alquilo C1-4 no sustituido o sustituido； R2 es hidrogeno, alquilo C1-4 o halogeno； y R3 es alquilo C1-4 sustituido con halogeno, ciano, entre otros. Son compuestos preferidos: N- (3-((2-((1-ciclopropil-1H-pirazol-4-il)amino)pirrolo[2,1-f][1,2,4] triazin-4-il)oxi)-4-fluorofenil) acrilamida； N-(3-((2-((4-(4-metilpiperazin-1-il)fenil)amino)pirrolo[2,1-f][1,2,4]triazin-4-il)oxi) fenil)acrilamida, entre otros. Dichos compuestos son inhibidores de cinasas JAK (Janus cinasa) y/o BTK (Tirosin cinasa de Bruton), siendo utiles en el tratamiento o prevencion de enfermedades inflamatorias, autoinmunes, proliferativas, cancer o tumor, entre otros. Tambien se refiere a composiciones que los contiene.
