BOLLBUCK, Birgit,ROEHN, Till,MILTZ, Wofgang,MARKERT, Christian
申请号：
PE2016000846
公开号：
PE20160899A1
申请日:
2014.12.18
申请国别(地区):
PE
年份:
2016
代理人:
摘要：
The invention relates to a derivative of butadisobutylenic acid (I),Where R1 is Oh or NH2； it is O, s or CH2； x1, X2, X3 and X4 are n； or x1, X2, X3 and X4 are selected from n, NH, provided that at least two x1, X2, X3 or X4 are n or NH； R2 is C1-C6 tar, etc. The most popular compounds are: propionic acid (R) - 3-amine-4 - (5 - (4 - (benzo [d-124； tiazol-2-ilxi) phenyl) - 2h-tetrazol-2-il) butane； acido (R) - 3-amino-4 - (5 - (chloropyridine-2-il) phenyl) - 2h-tetrazol-2-il； and other compounds. He also mentioned an understandable composer of pharmacology These compounds are A4 hydroxy acrylic acid inhibitors (lt4h),It is useful in the treatment of inflammation, such as arthritis, allergy, etcLa presente invencion se refiere a derivados de acido heteroaril butanoico de formula (I), en donde R1 es OH o NH2； Y es O, S o CH2； X1, X2, X3 y X4 son N； o X1, X2, X3 y X4 se seleccionan de N, NH, entre otros, siempre que al menos dos de X1, X2, X3 o X4 sean N o NH； R2 es alquilo C1-C6, entre otros. Son compuestos preferidos: acido (R)-3-amino-4-(5-(4-(benzo[dtiazol-2-iloxi)fenil)-2H-tetrazol-2-il)butanoico； acido (R)-3-amino-4-(5-(4-((5-cloropiridin-2-il)oxi)fenil)-2H-tetrazol-2-il)butanoico； entre otros. Tambien se refiere a una composicion farmaceutica que lo comprende. Dichos compuestos son inhibidores de leucotrieno A4 hidrolasa (LTA4H), siendo utiles en el tratamiento de trastornos de la inflamacion como artritis, alergias, entre otros
