BAE, IN HWAN,SON, JUNG BEOM,HAN, SANG MI,KWAK, EUN JOO,KIM, HO SEOK,SONG, JI YOUNG,BYUN, EUN YOUNG,JUN, SEUNG AH,AHN, YOUNG GIL,SUH, KWEE HYUN
申请号：
PE2014001048
公开号：
PE20141404A1
申请日:
2012.12.27
申请国别(地区):
PE
年份:
2014
代理人:
摘要：
It refers to a compound extracted from Tien [3,2-d] pyridine (I), wherein a is h, hydrocarbyl (C1-C6),Bicycle (C3-C6),W is O, s, s (o), among other things,Among others, x E and y are ch or n respectively； Z is h, asphalt (C1-C3) or nr3r4, wherein R3 and R4 are h, asphalt (C1-C6), respectively,R1 is, inter Alia, h, halogen, tar (C1-C3) or Alcoy (C1-C3)；R2 is h, halogen, CF3, NO2, etc., M is 0 to 5, n is 0 to 2. The most popular compounds are: 4-amine-n (1 - ((4-chlorophenyl) amine) - 6-methylisoquinine-5-il) tieno [3, 2-D] pirimidin-7-carboxamida； 4-amine-n - (6-methyl-1 - ((3 - (trifluoroactane sulfonate) Fen) amine) isoquinine-5-il) tieno [3, 2-D] pirimidin-7-carboxamida； and others. He also mentioned a pharmaceutical composer These compounds are quinasa inhibitors of proteins and are useful in the treatment of gastric cancer, melanoma and psoriasis.SE REFIERE A COMPUESTOS DERIVADOS DE TIENO[3,2-d]PIRIMIDINA DE FORMULA (I) DONDE A ES H, ALQUILO(C1-C6), CICLOALQUILO(C3-C6), ENTRE OTROS； W ES O, S, S(O), ENTRE OTROS； X E Y SON CADA UNO CH O N； Z ES H, ALQUILO(C1-C3) O NR3R4, DONDE R3 Y R4 SON CADA UNO H, ALQUILO(C1-C6), ENTRE OTROS； R1 ES H, HALOGENO, ALQUILO(C1-C3) O ALCOXI(C1-C3)； R2 ES H, HALOGENO, -CF3, -NO2, ENTRE OTROS； m ES DE 0 A 5； n ES DE 0 A 2. SON COMPUESTOS PREFERIDOS: 4-AMINO-N-(1-((4-CLOROFENIL)AMINO)-6-METILISOQUINOLIN-5-IL)TIENO[3,2-d]PIRIMIDIN-7-CARBOXAMIDA； 4-AMINO-N-(6-METIL-1-((3-(TRIFLUOROMETIL)FENIL)AMINO)ISOQUINOLIN-5-IL)TIENO[3,2-d]PIRIMIDIN-7-CARBOXAMIDA； ENTRE OTROS. TAMBIEN SE REFIERE A UNA COMPOSICION FARMACEUTICA. DICHOS COMPUESTOS SON INHIBIDORES DE QUINASAS DE LAS PROTEINAS SIENDO UTILES EN EL TRATAMIENTO DEL CANCER GASTRICO, MELANOMA, PSORIASIS
