WANG, Zhicheng,PETRASSI, Hank Michael James,CHOI, Ha-Soon,NATALA, Srinivasa Reddy,LAJINESS, James Paul,NGUYEN, Bao
申请号：
PE2016002192
公开号：
PE20161432A1
申请日:
2015.05.12
申请国别(地区):
PE
年份:
2017
代理人:
摘要：
The invention refers to a formula compound (I) or a pharmaceutically acceptable salt, wherein: "..." is a simple or double link； a is cr8ar8b, N9, O； R8a, r8b and R9 are h or C1-C6 tar； R0 is h, C1-C6 tar； R1 is halogen, cyanogen, C (o) R11, among others； R11 is C1-C6 tar； R3 is C1-C6 tar, C1-C6 halide； R2 and R4 are h or C1-C6 or R2 and R4 asphalt, which form a bicycle washer combined with a bicycle ring； R5 is h or C1-C6 or R5 and R10 which form a 5 or 6 member ring combined with a bicycle ring；R6 and R7 are h or C1-C6 He also mentioned a pharmaceutical composer The most popular compounds are: (1R, 2R, 3S, 4S) - N - (3, 4-dichlorophenyl) - N - (3, 4-dichlorophenyl) - 3 - (2-ethylsulfonamide) pyridine-4-il) - 7-oxabirine [2.1] heptone-2-carboxamida； 2 - ((1R, 2S, 3R, 4S) - 3 - (3 - (4-chlorophenyl) - 1, 2, 4-oxadiazol-5-il) - 7-hydroxypropyl [2.1] phenylethyl ammonium formate； others. He also mentioned a treatment This compound improves or prevents joints or injuries in mammalsLa presente invencion se refiere a un compuesto de formula (I) o una sal farmaceuticamente aceptable del mismo donde: “-----“ son enlaces simples o dobles； A es CR8aR8b, NR9, o O；R8a, R8b y R9 son H o alquilo C1-C6； R0 es H, alquilo C1-C6； R1 es halo, ciano, C(O)R11, entre otros； R11 es H o alquilo C1-C6； R3 es alquilo C1-C6, haloalquilo C1-C6, entre otros； R2 y R4 son H o alquilo C1-C6 o R2 y R4 forman un ciclopropilo fusionado con el anillo biciclico que contiene A； R5 es H o alquilo C1-C6 o R5 y R10 forman un anillo de 5 o 6 miembros fusionado con el anillo biciclico que contiene A； R6 y R7 son H o alquilo C1-C6. Tambien se refiere a una composicion farmaceutica. Son compuestos preferidos: (1R,2R,3S,4S)-N-(3,4-diclorofenil)-3-(2-etilsulfonamido)piridin-4-il)-7-oxabiciclo[2.2.1]heptano-2-carboxamida； 2-((1R, 2S,3R,4S)-3-(3-(4-clorofenil)-1,2,4-oxadiazol-5-il)-7-oxabiciclo[2.2.1]heptano-2-carboxamido)benzoato de etilo； entre otros. Tambien se refiere a un metodo de tratamiento. Dichos compue
