It refers to a bicycle non bicycle derivative, where: Dial line is a simple or double link； X is C, C (o),Where n or C and N may be replaced； L1 is a direct link or a link selected from NH.-NHC（O）-O-NHS（O）2-；L2 is from C (o)it is life.Among other things, C1 is a single ring composed of 5-6 members, including 1-4 heteromorphisms selected from n, NH, O-C (o).Cy2 is a single ring, consisting of 4-12 members, including 0-3 heterogeneity selected from n, NH, or s； R1 is hydrogen, tar, etc.； R2 and R3 are hydrogen, tar or combined to form an oxo group； R4 is hydrogen, tar, etc.； n is 1 or 2. The most popular compounds are: 4 - (4-chlorobenzene) - 7 - (3,5-dimethylisocyanxazol-4-il) - 6-methoxy-3,4-dihydro-benzofuran [b] [1,4] oxygen, 6 - (3,5-dimethylisocyanxazol-4-il) - 7-methoxy-1 - ((5-methoxypyridine-2-il) a) quine-2 (1H) ona. He also mentioned a pharmacology composer and a therapeutic approach. These compounds are bromine control inhibitors (BRD) that can be used to treat autoimmune diseases.Inflammation or cancerSe refiere a derivados heterociclicos biciclicos de formula I, donde: la linea punteada es un enlace simple o doble； X es C, C(O), N u O en donde C y N pueden estar sustituidos； L1 es un enlace directo o un ligador seleccionado de NH-, -NHC(O)- o –NHS(O)2-； L2 es un ligador seleccionado de –C(O)-, S(O)2-, entre otros； Cy1 es un anillo monociclico de 5-6 miembros que contiene 1-4 heteroatomos seleccionados de N, NH, O o –C(O)-； Cy2 es un anillo monociclico de 4-12 miembros que contiene 0-3 heteroatomos seleccionados de N, NH, O o S； R1 es hidrogeno, alquilo, entre otros； R2 y R3 son hidrogeno, alquilo o juntos forman un grupo oxo； R4 es hidrogeno, alquilo, entre otros； n es 1 o 2. Son compuestos preferidos: 4-(4-clorobencil)-7-(3,5-dimetilisoxazol-4-il)-6-metoxi-3,4-dihidro-2H-benzo[b][1,4]oxazina, 6-(3,5-dimetilisoxazol-4-il)-7-metoxi-1-((5-metoxipiridin-2-il)metil)quinolin-2(1H)ona； entre otros. Tambien se refiere a una composicion farmaceutica y a un metod
