AKIREDDY, SRINIVASA RAO,BHATTI, BALWINDER SINGH,JOSEPH, RONALD,MELVIN, MATT S.,SPEAKE, JASON,XIAO, YUNDE,YOHANNES, DANIEL
申请号：
PE2012002210
公开号：
PE20130775A1
申请日:
2011.05.24
申请国别(地区):
PE
年份:
2013
代理人:
摘要：
It refers to the antagonistic compounds of non competitive nicotine formula receiver (I): R1 and R2 are h, C1-C6 tar, C1-C6 tar and other substitutes respectively； R3 is h, C1-C6 tar, R7 is a single h, C1-C6 tar or alcox of C1-C6； L1 is the selected cr8r9 group connector, Cr8r9cr10r11, O； R8, R9, R10, R11 is h, C1-C6 tar,L2 is a connector selected from the CH2, CH2CH2, CH2CH2, and ch2ch2ch2ch22ch2 groups. The most popular compounds are: n hydrochloride, 3-dimethylhelix [bicycle [2.2.1] heptabromo-2.1 '- cyclopropane] - 3-amine； n hydrochloride, 3-dimethylhelix [bicycle] October [5] benzene-2.1' - Cyclopentan] - 3-amine and N hydrochloride, 3-dimethylhelix [bicycle [2.2] - octano-2.1-cyclopentan] - 3-A, etc. These compounds are useful in the treatment or prevention of diseases controlled by neuronicotine receptors.SE REFIERE A COMPUESTOS ANTAGONISTAS NO COMPETITIVOS DE RECEPTORES NICOTINICOS DE FORMULA (I) DONDE: R1 Y R2 INDIVIDUALMENTE ES H, ALQUILO DE C1-C6, ALQUILO C1-C6 SUSTITUIDO CON ARILO, ENTRE OTROS； R3 ES H, ALQUILO DE C1-C6, R7 ES INDIVIDUALMENTE H, ALQUILO DE C1-C6, O ALCOXI DE C1-C6； L1 ES UN CONECTOR SELECCIONADO DEL GRUPO FORMADO POR CR8R9, CR8R9CR10R11, O； R8,R9,R10,R11 ES H, ALQUILO C1-C6 , L2 ES UN CONECTOR SELECCIONADO DEL GRUPO FORMADO POR CH2, CH2CH2, CH2CH2CH2 Y CH2CH2CH2CH2. SON COMPUESTOS PREFERIDOS: CLORHIDRATO DE N,3-DIMETILESPIR[BICICLO[2.2.1]HEPTANO-2,1´-CICLOPROPAN]-3-AMINA； CLORHIDRATO DE N, 3-DIMETILESPIRO[BICICLO]OCT[5]ENO-2,1´-CICLOPENTAN]-3-AMINA Y CLORHIDRATO DE N,3-DIMETILESPIRO[BICICLO[2.2.2]OCTANO-2,1´-CICLOPENTAN]-3-AMINA, ENTRE OTROS. DICHOS COMPUESTOS SON UTILES EN ELTRATAMIENTO O PREVENCION DE UNA ENFERMEDAD MEDIADA POR UN RECEPTOR NICOTINICO NEURONAL.
