BALINT, Balazs,CSEKEI, Marton,SZABO, Zoltan,KOTSCHY, Andras,CHANRION, Maia,GENESTE, Olivier,CHEN, I-Jen,DAVIDSON, James Edward Paul,SIPOS, Szabolcs,ONDI, Levente,PROSZENYAK, Agnes
申请号：
PE0027172017
公开号：
PE14912018A1
申请日:
2016.06.22
申请国别(地区):
PE
年份:
2018
代理人:
摘要：
Bicyclic compounds referred to Derivatives of formula (i) wherein a represents the Group: (a), which is attached to the Group 1 W and 2 attached to the phenyl ring is a ring furilo and,Tienilo or pirrolilo x1, X3, X4 and X5 independently of one another, is an atom of carbon or nitrogen x2 is C - R21 or a nitrogen Atom.R1 is a Halogen Atom, an alkyl group (C1 - C6) linear or branched, a group alquenilo (C2 - C6) linear or branched, among others R2, R3, R4 and R5 independently of one another,An Atom is Hydrogen, halogen, alkyl group (C1 - C6) linear or branched, a group alquenilo (C2 - C6) linear or branched, among others, among others, R6 and R7 independently of one another,Is a Halogen Atom, an alkyl group (C1 - C6) linear or branched, a group Alquinilo (C2 - C6) linear or branched, among others W is - CH2 -, - NH -, or an oxygen Atom R8 is a hydrogen Atom,Alkyl (C8 C1 -) linear or branched, an aryl Group, among others R9 is a hydrogen Atom, an alkyl group (C1 - C6) linear or branched, a group alquenilo (C2 - C6)Among others, R10 is a hydrogen Atom, an alkyl group (C1 - C6) linear or branched, a group alquenilo (C2 - C6) linear or branched R14 is a hydrogen Atom,A Hydroxy group or a group hidroxialquilo (C1 - C6) n is an integer equal to 0 OR 1.It also relates to processes for preparing these compounds and to pharmaceutical compositions comprising these Compounds, which are useful as pro apoptotic agents.In the treatment of Cancer and autoimmune diseases.Referido a compuestos derivados biciclicos de formula (I), en donde: A representa el grupo (a), en la que 1 esta unido al grupo W y 2 unido al anillo fenilo E es un anillo furilo, tienilo o pirrolilo X1, X3, X4 y X5 independientemente uno de otro, es un atomo de carbono o nitrogeno X2 es C-R21 o un atomo de nitrogeno. R1 es un atomo de halogeno, un grupo alquilo(C1-C6) lineal o ramificado, un grupo alquenilo(C2-C6) lineal o ramificado, entre otros R2, R3, R4 y R5 independientemente uno de otro, es un atomo de hidrog
