Systems, methods, and apparatuses are provided for radiation treatment with multiple imaging elements. One system includes a first imaging element configured to generate a first observation of a first object, the first observation of the first object being generated at a first time, wherein the first object is associated with a volume of interest (VOI), wherein the VOI is a volume within a body of a patient. The system further includes a second imaging element configured to generate a first observation of a second object, wherein the first observation of the second object is generated at a second time, and the second object is associated with the VOI. The system further includes one or more processors configured to determine a first positioning of the VOI based at least in part on the first observation of the first object and the first observation of the second object, determine a third time for the first imaging element based at least in part on a positioning parameter associated with the first positioning of the VOI, and generate a second observation of the first object at the third time.
