Systems and methods are provided for imaging observation timing based on radiation treatment system element delay. One system includes an imaging element configured to generate a first observation of an object, the first observation being generated at a first time, wherein the object is associated with a volume of interest (VOI). The system is further configured to determine a plurality of positionings of the VOI based at least in part on the first observation of the object, determine a first radiation treatment system configuration based at least in part on one or more parameters of the plurality of positionings of the VOI, configure the radiation treatment system based on the first radiation treatment system configuration, and aid in administering of radiation, by a radiation treatment system element of the radiation treatment system, to at least a portion of the patient based on the first radiation treatment system configuration.
