Systems, methods, and apparatuses are provided for configuring a radiation treatment system based on a plurality of volume of interest (VOI) positioning. One system includes an imaging element configured to generate a first observation of an object, the first observation being generated at a first time, wherein the object is associated with a volume of interest (VOI), and the VOI includes a volume within a body of a patient. The system further includes determining a first positioning of the VOI based at least in part on the first observation of the object, determining a second time for the imaging element based at least in part on a positioning parameter associated with the first positioning, and a time offset, and generating a second observation of the object at the second time.
