Systems, methods, and apparatuses are provided for targeting diseased tissue with a radiation beam. One system includes an imaging element configured to generate a first observation of an object, the first observation generated at a first time, the object associated with a volume of interest (VOI), the VOI comprising a volume within a body of a patient. The system further includes one or more processors configured to determine a first positioning of the VOI based at least in part on the first observation of the object determine a second time for the imaging element based at least in part on a positioning parameter associated with the first positioning of the VOI, and generate a second observation of the object at the second time.
