Systems and methods in accordance with embodiments of the invention implement non-aggravating thermal treatment packs. In one embodiment, a non-aggravating thermal treatment pack includes: a vinyl-based encasing and a gelatinous material disposed within the vinyl-based encasing, itself including: a solute that is a Cell-O—CH2—COO−Na+ (CMC)+H2O mixture and a solvent that is propylene glycol where the molar concentration of the solute/solvent mixture is between approximately 0.55 mol/L and approximately 0.75 mol/L.