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heterocyclic compound
专利权人:
Takeda Pharmaceutical Company Limited
发明人:
YOSHIDA, Masato,NAGAMIYA, Hiroyuki,OHBA, Yusuke,SETO, Masaki,YOGO, Takatoshi,SASAKI, Satoshi,TOKUNAGA, Norihito,ASO, Kazuyoshi
申请号:
ES14773826
公开号:
ES2661012T3
申请日:
2014.03.27
申请国别(地区):
ES
年份:
2018
代理人:
摘要:
A compound represented by formula (I): ** (See formula) ** wherein R1 is (1) a C1-6 alkyl group optionally substituted with 1 to 5 substituents selected from (a) a halogen atom, (b ) a C3-8 cycloalkyl group optionally substituted with 1 to 3 C1-6 alkyl groups, (c) a C1-6 alkoxycarbonyl group, and (d) a carbamoyl group, (2) an optionally C3-10 cycloalkyl group substituted with 1 to 3 C1-6 alkyl groups, or (3) a C6-14 aryl group optionally substituted with 1 to 3 substituents selected from (a) a halogen atom, (b) a C1-6 alkyl group optionally substituted with 1 to 3 halogen atoms, and (c) a cyano group; R2 is a hydrogen atom or a cyano group; R3 is a C1-3 alkyl group optionally substituted with 1 to 3 substituents selected from a halogen atom and a C1-6 alkoxy group; R4 is (1) a C1-6 alkyl group optionally substituted with 1 to 3 substituents selected from (a) a halogen atom, (b) a cyano group, (c) a hydroxy group, (d) an optionally mono amino group or disubstituted with C1-6 alkyl-carbonyl group (s), and (e) a carbamoyl group optionally mono or disubstituted with C1-6 alkyl group (s), and (2) a C3-10 cycloalkyl group, (3) a C6-14 aryl group optionally substituted with 1 to 3 substituents selected from a carbamoyl group optionally mono or disubstituted with C1-6 alkyl group (s), (4) a 5 or 6 membered non-aromatic heterocyclic group having an atom of oxygen, or ...Un compuesto representado por la fórmula (I): **(Ver fórmula)** en donde R1 es (1) un grupo alquilo C1-6 opcionalmente sustituido con 1 a 5 sustituyentes seleccionados de (a) un átomo de halógeno, (b) un grupo cicloalquilo C3-8 opcionalmente sustituido con 1 a 3 grupos alquilo C1-6, (c) un grupo alcoxi-C1-6-carbonilo, y (d) un grupo carbamoilo, (2) un grupo cicloalquilo C3-10 opcionalmente sustituido con 1 a 3 grupos alquilo C1-6, o (3) un grupo arilo C6-14 opcionalmente sustituido con 1 a 3 sustituyentes seleccionados de (a) un átomo de halógeno, (b) un grupo alquilo C1-6 opcionalmente sustituido con 1 a 3 á
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