AEBI, JOHANNES,BINGGELI, ALFRED,GREEN, LUKE,HARTMANN, GUIDO,MAERKI, HANS P.,MATTEI, PATRIZIO
申请号：
ES10766012
公开号：
ES2455266T3
申请日:
2010.10.05
申请国别(地区):
ES
年份:
2014
代理人:
摘要：
A compound with the formula (I) ** Formula ** in which A is aryl, heteroaryl, arylmethyl or heteroarylmethyl, wherein said rings are optionally substituted by one to three substituents independently selected from the group that includes a halogen, aryl, heteroaryl, C 1-6 alkyl, C 1-6 haloalkyl, C 1-6 alkoxy and C 1-6 haloalkoxy； E is CH2 or O； F is CH2, O, N (R8), S, SO or SO2； G is a simple bond, CH2, or CH2CH2, with the proviso that when E is O then F is not O, S, SO or SO2； L is a bond, NH-C (>； = O), NH-C (>； = S), or CH>； = CH-C (>； = O)； R1, R2 and R3 are independently selected from the group that includes: - hydrogen, - C1-6 alkyl, which is optionally substituted by one to three substituents independently selected from the group that includes hydroxy, C1 alkoxy -6, carboxy, carbamoyl, aminocarbonyl mono or disubstituted by C1-6 alkyl and C1-6 alkoxycarbonyl, aryl and heteroaryl, wherein said heteroaryl and aryl rings are optionally substituted by one to three substituents independently selected from the group which includes a halogen, C 1-6 alkyl, C 1-6 haloalkyl, C 1-6 alkoxy and C 1-6 haloalkoxy-C 3-7 cycloalkyl, o-aryl； R4 and R5 are independently selected from the group that includes: hydrogen, C1-6 alkyl, which is optionally substituted by one to three substituents independently selected from the group that includes amino, hydroxy, carboxy, carbamoyl, aminocarbonyl mono or disubstituted by C1-6 alkyl and C1-6 alkoxycarbonyl, or C3-7 cycloalkyl, which is optionally substituted by one to three substituents independently selected from the group including amino, hydroxy, carboxy, carbamoyl, aminocarbonyl mono or disubstituted by C1-6 alkyl and C1-6 alkoxycarbonyl； or R4 and R5, together with the carbon atom to which they are attached, form a C3-7 cycloalkyl or heterocyclyl which is optionally substituted by one to three substituents independently selected from the group including C1-4 alkyl, haloalkyl C1-4 and a halogen； R6 and R7 are independently s
