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Substituted tricyclic benzimidazoles as kinase inhibitors
专利权人:
发明人:
RZYMSKI, Tomasz,ZAREBSKI, Adrian,DREAS, Agnieszka,OSOWSKA, Karolina,KUCWAJ, Katarzyna,FOGT, Joanna,CHOLODY, Marek,GALEZOWSKI, Michal,CZARDYBON, Wojciech,HORVATH, Raymond,WIKLIK, Katarzyna,MILIK, Mariu
申请号:
ES13786679
公开号:
ES2628046T3
申请日:
2013.11.07
申请国别(地区):
ES
年份:
2017
代理人:
摘要:
A compound of formula (I) ** Formula ** wherein X1, X2 and X3 are each independently selected from the group consisting of H, F, Cl, Br, I, -OT1, - N (T2) (T3 ), -NHC (>; = O) T4, nitro, cyano, cyclopropyl and -C1-3 alkyl, with the proviso that at least two substituents selected from X1, X2 and X3 are each independently selected from the group consisting of F, Cl, Br and I; Z1 and Z2 are each independently selected from the group consisting of H, -C1-6 alkyl, -OT1 and -N (T2) (T3); Z3 and Z4 are taken together to form an oxo group on the carbon atom to which they are attached; or Z3 and Z4 are each independently selected from the group consisting of H, -C1-6 alkyl, -OT1 and -N (T2) (T3); Z5 and Z6 are taken together to form an oxo group on the carbon atom to which they are attached; or Z5 and Z6 are each independently selected from the group consisting of H, -C1-6 alkyl, -OT1 and -N (T2) (T3); X4 is absent or is selected from the group consisting of -NR4-, -N (R4) (CH2) -, -C (>; = O) NH- and -C (>; = O) -; R4 is selected from H and -C 1-6 alkyl; Y1 is selected from the group consisting of H, -C 1-6 alkyl and a saturated or unsaturated aromatic carbocycle or heterocycle of 4 to 7 members, with the proviso that the point of attachment in said heterocycle is carbon if X4 is -NR4- or -C (>; = O) NH-, wherein said -C1-6 alkyl is optionally substituted with one or more substituents independently selected from -OT1, -ST1, -N (T2) (T3) and a saturated heterocycle of 5 to 6 members, and wherein said saturated or unsaturated aromatic carbocycle or heterocycle of 4 to 7 members is optionally substituted with one or more substituents independently selected from F, Cl, Br, I, -C (>; = O) H, -OT1 , -N (T2) (T3), -C (>; = O) N (T2) (T3), -C (>; = O) OT1, - ST1 and -C1-3 alkyl, wherein said -C1 alkyl 3 is optionally substituted with one or more substituents independently selected from -OT1 and -N (T2) (T3); T1, T2 and T3 are each independently selected from H and -C
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