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Phenylureas and substituted phenylamides as vanilloid receptor ligands
专利权人:
Medifron DBT Inc.
发明人:
FRANK, Robert,BAHRENBERG, Gregor,CHRISTOPH, Thomas,SCHIENE, Klaus,DE VRY, Jean,DAMANN, Nils,FRORMANN, Sven,LESCH, Bernhard,LEE, Jeewoo,KIM, Yong-Soo,KIM, Myeon-Seop,SAUNDERS, Derek John,STOCKHAUSEN, H
申请号:
ES10720271
公开号:
ES2640257T3
申请日:
2010.05.06
申请国别(地区):
ES
年份:
2017
代理人:
摘要:
Substituted compounds of the general formula (If) ** Formula ** where X represents CR3 or N, representing R3 H, methyl, ethyl, n-propyl, isopropyl, n-butyl, sec-butyl, tert-butyl, or CF3, A represents N or CR5b, R1 represents the substructure (T1) ** Formula **, where Y represents C (>; = O), O, S, S (>; = O) 2, NH-C (>; = O) or NR12 R12 H being methyl, ethyl, n-propyl, isopropyl, n-butyl, sec-butyl, tert-butyl, S (>; = O) 2-methyl, or represents 0 or 1, R11a and R11b mean, in each independently of each other, H, methyl, ethyl, n-propyl, isopropyl, n-butyl, sec-butyl, tert-butyl, m represents 0, 1 or 2, Z represents saturated or unsaturated (C1-4) alkyl, branched or linear, unsubstituted or substituted once or several times with one or more substituents selected in each case independently from each other from the group consisting of F, Cl, Br, I, OH, O-C 1-4 alkyl, saturated or unsaturated cycloalkyl1 (C3-10), morpholinyl, tetrahydropyranyl, piperidinyl, 4-methylpiperazinyl, piper idinyl, in each case unsubstituted or substituted once or several times with one or more substituents selected in each case independently from each other from the group consisting of F, Cl, Br, I, OH, O (C1-4) alkyl and (C1-4) alkyl; phenyl or pyridyl, in each case unsubstituted or substituted once or several times with one or more substituents selected in each case independently from each other from the group consisting of F, Cl, Br, I, CN, OH, O-alkyl (C1 -4), OCF3, (C1-4) alkyl, CF3, SH, S-(C1-4) alkyl, SCF3, R2 represents H, F, Cl, Br, I, CF3, CN, methyl, ethyl, n- propyl, isopropyl, n-butyl, sec-butyl, tert-butyl, cyclopropyl, cyclobutyl, unsubstituted or substituted phenyl once or several times with one or more substituents independently selected from each other from the group consisting of (C1-4) alkyl , O (C1-4) alkyl, F, Cl, Br, I, CF3 and OCF3, R4 represents H, methyl, ethyl, n-propyl or isopropyl, R5a represents H or CH3, if A means N, or H, methyl, ethyl, n-propyl, isop
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