The University Court of The University of Aberdeen
发明人:
GREIG, Iain Robert,VAN'T HOF, Robert Jurgen,RALSTON, Stuart Hamilton
申请号：
ES08718826
公开号：
ES2561163T3
申请日:
2008.03.20
申请国别(地区):
ES
年份:
2016
代理人:
摘要：
A compound selected from the compounds of the following formula and the pharmaceutically acceptable salts, hydrates and solvates thereof: ** Formula ** in which: Ar1-Ar2- is independently a group of the following formula: ** Formula ** q is independently 0, 1, 2, 3 or 4； r is independently 0, 1, 2, 3, 4 or 5； each RP is independently a substituent of the ring； -RN is independently -H or a C1-6 alkyl； -Ar3- is independently 1,3-phenylene or 1,4-phenylene, and is unsubstituted or independently substituted with one or more substituents, -RAR3, wherein each RAR3 is independently a ring substituent； -Z is independently -OH or -O-W； -J- is independently -Ralq-； -Ralq- is independently a saturated aliphatic C1-5 alkylene, and is unsubstituted or independently substituted with one or more substituents -RAA, in which each -RAA is independently: -F, -Cl, -Br, -I, - OH or -OMe； -W is independently: -RE1, -C (>； = O) -RE2, -C (>； = O) -O-RE3, -C (>； = O) -OS (>； = O) 2ORE4, -C (>； = O) - (CH2) nC (>； = O) ORE5, -C (>； = O) - (CH2) n-NRNE1RNE2, -C (>； = O) - (CH2) n-NRNE3-C (>； = O ) RE6, -C (>； = O) - (CH2) nC (>； = O) -NRNE4RNE5 or -P (>； = O) (ORE7) (ORE8)； in which: each n is independently 1, 2, 3 or 4； and each of RE1, RE2, RE3, RE4, RE5, RE6, RE7, RE8, RNE1, RNE2, RNE3, RNE4 and RNE5 is independently -H, C1-3 alkyl, phenyl or -CH2-phenyl； wherein each phenyl is optionally substituted with one or more groups selected from: -F, -Cl, -Br, -I, -RA3, -CF3, -OH, -ORA3, -OCF3, -NH2, -NHRA3, - NRA3 2, -C (>； = O) NH2, -C (>； = O) NHRA3 and -C (>； = O) NRA3 2, where each RA3 is independently C1-4 alkyl； wherein each substituent of the ring is independently: -F, -Cl, -Br, -I, -RD1, -CF3, -OH, -ORD1, -OCF3, -SH, -SRD1, -CN, -NO2, -NH2 , -NHRD1, -NRD1 2, -NRN1RN2, -C (>； = O) OH, -C (>； = O) ORD1, -C (>； = O) NH2, -C (>； = O) NHRD1, -C ( >； = O) NRD1 2, -C (>； = O) NRN1RN2, -NHC (>； = O) RD1, -NRD1C (>； = O) RD1, -NHC (>； = O) ORD1, -NRD
