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Systems of transdermal administration of beta-lactam antibiotics
专利权人:
CHONGXI;YU
发明人:
YU, CHONGXI
申请号:
ES06832186
公开号:
ES2547258T3
申请日:
2006.12.10
申请国别(地区):
ES
年份:
2015
代理人:
摘要:
Compound having a general formula of Structure 5 ** Formula ** in which X is selected from the group consisting of O, CH2, S and NH; Y is selected from the group consisting of H, OH, OR5, NHCHO, CH2CH2 NHC (>; = NR7) NHR7, OCOCH3, OCH3, OC2H5, CH3SO3, NO2, CN, CF3, OCF3, F, Br, I, and Cl; ** Formula ** is selected from the group consisting of ** Formula ** in which, Z is selected from the group consisting of S, O, SO, SO2, NH, CHCH3, CHCH2CH3, and CH2; -X1 is selected from the group consisting of: -H, -OH, -OCH3, -OC2H5, OC3H7, -CONH2, - CH2OCONH2, -OCOCH3, -CH2 OCOCH3, -CH2OCH3, -CH3, -C2H5, -C3H7, - C4H9, -C5H11, -C6H13, -CI, -F, -Br, -I, -HC>; = CHCH3, -HC>; = CH2, - CH2OCH3, -S (CH2) n-NHR7, ** Formula ** en which R5 is selected from the group consisting of H, CONH2, CH2CH2OR6, CH2CH2N (CH3) 2, CH2CH2N (5 CH2CH3) 2, F, Br, I, alkyl residues having 1 to 12 carbon atoms, alkyloxy residues which they have 1 to 12 carbon atoms, alkenyl residues having up to 12 carbon atoms and alkynyl residues having up to 12 carbon atoms, aryl residues, heteroaryl residues, CORN + R1R2HA- and -RN + R1R2HA-; R6 is selected from the group consisting of H, F, Cl, Br, I, Na +, K +, one of any alkyl, alkyloxy, alkenyl or alkynyl residues having up to 12 carbon atoms, aryl or heteroaryl residues, CORN + R1R2HA- or RN + R1R2HA-; R7 is selected from the group consisting of H, CH3, C3H5, CF3, COCH3, C3H7, C4H9, C5H11, CONH2, COR6, COR5, CO-RN + R1R2HA- and -RN + R1R2HA-; R8 is selected from the group consisting of H, CH3, C2H5, CF3, CH2CH2F, CH2CH2CI, CH2CH2Br, CH2CH2I, 15 CH2CHF2, CH2CF3 CH2F, CH2CI, CH2Br, CH2I, CH2NR6R7, CH (NHR7) CH2CONH2, C2H7, C2H7, C2H7, CONH2, CH2CONH2, CH2OCONH2, C (CH3) 2COOR6, CH (CH3) COOR6, CH2COOR6, COR6, COR5, CO-RN + R1R2HA- and -RN + R1R2HA-; X2 is selected from the group consisting of H, CH3, CH2 (CH2) nOR8, Cl, F, Br, I, NO2, CN, CF3, OCF3, NH2, CH3, C2H5, CONH2, CH2OCONH2, CH2COOR5, CH2 (CH2) nN (CH3) 2, CH2 (CH2) nSO3R5, C1-8 alkyl, C1-8 alkylthio
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