Aduro Biotech, Inc.;The Regents of The University of California
发明人:
KANNE, David, B.,LEONG, Meredith, Lai Ling,VANCE, Russell, E.,DUBENSKY, Thomas, W., Jr.,GLICKMAN, Laura, Hix,LEMMENS, Edward, Emile
申请号：
DK14800848
公开号：
DK2996473T3
申请日:
2014.05.18
申请国别(地区):
DK
年份:
2019
代理人:
摘要：
The present invention provides highly active cyclic-di-nucleotide (CDN) immune stimulators that activate DCs via a recently discovered cytoplasmic receptor known as STING (Stimulator of Interferon Genes). In particular, the CDNs of the present invention are provided in the form of a composition comprising one or more cyclic purine dinucleotides induce STING-dependent type I interferon production, wherein the cyclic purine dinucleotides present in the composition are substantially pure 2′,5′,2′,5′ and 2′,5′,3′,5′ CDNs, and preferably Rp,Rp stereoisomers thereof.
