DUBENSKY, THOMAS, W., JR,KANNE, DAVID, B,LEONG, MEREDITH, LAI LING,GLICKMAN, LAURA, HIX,VANCE, RUSSELL, E,LEMMENS, EDWARD, EMILE
申请号：
PH12015502438
公开号：
PH12015502438A1
申请日:
2015.10.22
申请国别(地区):
PH
年份:
2016
代理人:
摘要：
The present invention provides highly active cyclic-di-nucleotide (CDN) immune stimulators that activate DCs via a recently discovered cytoplasmic receptor known as STING (Stimulator of Interferon Genes). In particular, the CDNs of the present invention are provided in the form of a composition comprising one or more cyclic purine dinucleotides induce STING-dependent type I interferon production, wherein the cyclic purine dinuclotides present in the composition are substantially pure 2, 5, 2, 5 and 2, 5 ,3 ,5 CDNs, and prefereably Rp,Rp stereosiomers thereof.
