KATIBAH, George Edwin,KANNE, David,SUNG, Leonard,GAUTHIER, Kelsey,GLICKMAN, Laura Hix,LEONG, Justin,MCWHIRTER, Sarah, M.,DUBENSKY, Jr., Thomas, W.
申请号：
SG11201706756V
公开号：
SG11201706756VA
申请日:
2016.03.09
申请国别(地区):
SG
年份:
2017
代理人:
摘要：
The present invention provides highly active cyclic-di-nucleotide (CDN) immune stimulators that activate DCs via a recently discovered cytoplasmic receptor known as STING (Stimulator of Interferon Genes), In particular, the CDNs of the present invention are provided in the form of a composition comprising one or more cyclic purine dinucleotides induce human STING-dependent type I interferon production, wherein the cyclic purine dinucleotides present in the composition are 2′-fluoro substituted, bis-3′,5′CDNs, and most preferably one or more 2′,2″-diF-Rp,Rp, bis-3′,5′CDNs.
