Aduro Biotech, Inc.;The Regents of the University of California
发明人:
Dubensky, Jr., Thomas W.,Kanne, David B.,Leong, Meredith Lai Ling,Glickman, Laura Hix,Vance, Russell E.,Lemmens, Edward Emile
申请号：
AU2014268836
公开号：
AU2014268836B2
申请日:
2014.05.18
申请国别(地区):
AU
年份:
2018
代理人:
摘要：
The present invention provides highly active cyclic-di-nucleotide (CDN) immune stimulators that activate DCs via a recently discovered cytoplasmic receptor known as STING (Stimulator of Interferon Genes). In particular, the CDNs of the present invention are provided in the form of a composition comprising one or more cyclic purine dinucleotides induce STING-dependent type I interferon production, wherein the cyclic purine dinuclotides present in the composition are substantially pure 2', 5', 2', 5' and 2', 5 ',3 ',5' CDNs, and prefereably Rp,Rp stereosiomers thereof.
