DUBENSKY, Thomas, W., Jr.,KANNE, David, B.,LEONG, Meredith, Lai Ling,GLICKMAN, Laura, Hix,VANCE, Russell, E.,LEMMENS, Edward, Emile
申请号：
TN2015000408
公开号：
TN2015000408A1
申请日:
2015.09.10
申请国别(地区):
TN
年份:
2017
代理人:
摘要：
The present invention provides highly active cyclic-di-nucleotide (CDN) immune stimulators that activate DCs via a recently discovered cytoplasmic receptor known as STING (Stimulator of Interferon Genes). In particular, the CDNs of the present invention are provided in the form of a composition comprising one or more cyclic purine dinucleotides induce STING-dependent type I interferon production, wherein the cyclic purine dinuclotides present in the composition are substantially pure 2, 5, 2, 5 and 2, 5 ,3 ,5 CDNs, and prefereably Rp,Rp stereosiomers thereof.
