Arne Skerra,Gerald Beste,Frank Schmidt,Thomas Stibora
申请号:
US12654809
公开号:
US08158753B2
申请日:
2010.01.05
申请国别(地区):
US
年份:
2012
代理人:
摘要:
The invention relates to the production of novel proteins exhibiting bonding activity for certain ligands, the so-called anticalins. To this end, the structure of peptides of the lipocalin family is modified by amino acid replacement in their natural ligand binding pocket using generic engineering methods. Alike immunoglobulin, the anticalin thus obtained can be used to identify or bond molecular structures.