Cross-β structure comprising amyloid-binding proteins and methods for detection of the cross-β structure, for modulating cross-β structures fiber formation and modulating cross-β structure-mediated toxicity
Martin F. B. G. Gebbink;Louise M. J. Kroon-Batenburg;Onno W. Kranenburg;Barend Bouma
发明人:
Barend Bouma,Martin F. B. G. Gebbink,Onno W. Kranenburg,Louise M. J. Kroon-Batenburg
申请号：
US11982161
公开号：
US08158585B2
申请日:
2007.10.31
申请国别(地区):
US
年份:
2012
代理人:
摘要：
The invention relates to the field of biochemistry, molecular biology, structural biology and medicine. More in particular, the invention relates to cross-β structures and the biological role of these cross-β structures. In one embodiment, the invention discloses a method for modulating extracellular protein degradation and/or protein clearance comprising modulating cross-β(beta) structure formation (and/or cross-β structure-mediated activity) of the protein present in the circulation.
