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Imines as tissue inhibitors of methyltransferase
专利权人:
GLOBAL BLOOD THERAPEUTICS; INC.
发明人:
申请号:
ARP180101557
公开号:
AR112192A1
申请日:
2018.06.08
申请国别(地区):
AR
年份:
2019
代理人:
摘要:
1. Claim 1: a formula compound (1),Where: X is n or CR1;This is n or CR2P, Q, t and u are independent ch, C (when r8308o or r83099 is added);O n; if at least one but not more than two P, Q, t and u are n; Z is O, s, or 8310;R8310 is hydrogen, tar or cyclopentyl; R1 is hydrogen, tar, oxygen, halogen, halogenated tar, halogenated alcoxi or cyclopentyl; R2 is hydrogen, tar, alcoxi, halogenated, halogenated tar, halogenated alcoxi or cyclopentyl; R3 is - w-tar-r8311;Where: W is a link, NH, or s; tar is replaced by optional r831222;R831222 is halogenated, halogenated tar, halogenated alcoxi, hydroxy or alcoxi, while in tar, NH o can be used instead; r8311es-nr7491; r74955;1. In the case that r749195 and r74955 are independent hydrogen, tar or bittern tar, or r7491 and r74955 and the nitrogen attached to them, isomerized isomers, isomerized isomers or spiralized chloramines are formed, wherein, isomers; One or two alternatives without tar, halogen, halogen, hydroxyl and halogen can be used to replace non cyclopentadienylamide and ethylene oxide selectively; O r831181 is an isomer that binds to tar in a ring of carbon atoms and can optionally be replaced by one or two alternatives, which are selected independently of tar, halogenation, halogenation, hydrogen Xi, alcoxi and halogenated alcoxi;R83088 and r83099 are independent asphalt, aluminum, asphalt, cyclopentadiene, cyclopentadiene, halogen, hydroxyl, propoxy, cyanogen, n832222;No. 7580; No. 74966;5-8 members of acrylonitrile, hydroxyformic acid, carbamate, propylformic acid, propyloxyformic acid, phenyl, isobutylene, isoacrylonitrile, isoacrylonitrile, isoacrylonitrile, isoacrylonitrile, isoacrylonitrile or propylmethylamine helix A. one, two or three alternatives that do not contain asphalt, halogen, halogen, halogen oxygen, hydroxy, hydroxy, propoxy, nh483222 can be used alone or as another group of alternatives;A. leasing, diaklamino, carboxi, carboxialquilo and alcoxicarbio, wherein the tar of r83088 and r83099 can
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